Drug General Information (ID: DDIALFDCYW)
Drug Name			Chloramphenicol (ophthalmic)		Drug Info		Ofatumumab		Drug Info
Drug Type		Small molecule				Monoclonal antibody
Therapeutic Class		Antibiotics				Antineoplastics

Mechanism of Chloramphenicol (ophthalmic)-Ofatumumab Interaction (Severity Level: Moderate)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Chloramphenicol (ophthalmic)				Ofatumumab
Mechanism		Myelosuppressive effects				Myelosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Chloramphenicol (ophthalmic) and Ofatumumab

Recommended Action
Management		Concurrent use of chloramphenicol with other bone marrow depressing agents should be avoided.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Sim SM, Back DJ, Breckenridge AM "The effect of various drugs on the glucuronidation of zidovudine (azidothymidine AZT) by human liver microsomes." Br J Clin Pharmacol 32 (1991): 17-21. [PMID: 1909542]