Details of Drug

Details of Drug

 Drug General Information (ID: D0314)
  Drug Name
Chloramphenicol (ophthalmic)
  Drug Type Small molecule
  Drug Synonymous
Alficetyn; Ambofen; Amphenicol; Amphicol; Amseclor; Anacetin; Aquamycetin; Austracil; Austracol; Biocetin; Biophenicol; CAF; CLM; Catilan; Chemiceticol; Chemicetin; Chemicetina; Chlomin; Chlomycol; Chloramex; Chloramfenikol; Chloramficin; Chloramfilin; Chloramphenicolum; Chloramsaar; Chlorasol; Chloricol; Chlornitromycin; Chloroamphenicol; Chlorocaps; Chlorocid; Chlorocide; Chlorocol; Chlorofair; Chloromax; Chloromycetin; Chloromycetny; Chloromyxin; Chloronitrin; Chloroptic; Chlorovules; Chlorsig; Cidocetine; Ciplamycetin; Cloramfen; Cloramfenicol; Cloramfenicolo; Cloramficin; Cloramical; Cloramicol; Cloramidina; Cloranfenicol; Cloroamfenicolo; Clorocyn; Cloromisan; Cloromissan; Clorosintex; Comycetin; Cylphenicol; Desphen; Detreomycin; Detreomycine; Dextromycetin; Doctamicina; Duphenicol; Econochlor; Embacetin; Emetren; Enicol; Enteromycetin; Erbaplast; Ertilen; Farmicetina; Fenicol; Globenicol; Glorous; Halomycetin; Hortfenicol; Interomycetine; Intramycetin; Intramyctin; Isicetin; Ismicetina; Isophenicol; Juvamycetin; Kamaver; Kemicetina; Kemicetine; Kloramfenikol; Klorita; Laevomycetinum; Leukamycin; Leukomyan; Leukomycin; Levomicetina; Levomitsetin; Levomycetin; Loromicetina; Loromisan; Loromisin; Mastiphen; Mediamycetine; Medichol; Micloretin; Micochlorine; Micoclorina; Microcetina; Mychel; Mycinol; Myscel; Novochlorocap; Novomycetin; Novophenicol; Oftalent; Oleomycetin; Opclor; Opelor; Ophthochlor; Ophtochlor; Optomycin; Otachron; Otophen; Pantovernil; Paraxin; Pentamycetin; Quemicetina; Rivomycin; Romphenil; Ronfenil; Ronphenil; Septicol; Sificetina; Sintomicetina; Stanomycetin; Synthomycetin; Synthomycetine; Synthomycine; Syntomycin; Tevcocin; Tevcosin; Tifomycin; Tifomycine;Tiromycetin; Treomicetina; Unimycetin; Veticol; Viceton; Ch loramex; Chloramfenikol [Czech]; Chloramphenicol crystalline; Chlormycetin R; Chlorocid S; Chlorocidin C; Chlorocidin C tetran; Chloroject L; Chloromycetny [Polish]; Cloramfenicolo [DCIT]; Cloroamfenicolo [Italian]; F armicetina; Isopto fenicol; Klorocid S; Normimycin V; Sintomicetine R; Sno Phenicol; Vice ton; I 337A; Ak-chlor; Alficetyn (TN); Amphicol (TN); Biomicin (TN); Brochlor (TN); CAF (pharmaceutical); Cedoctine (TN); Chlora-tabs; Chloramex (TN); Chloramphenicol & VRC3375; Chloramphenicolum [INN-Latin]; Chlorbiotic (Veterinary); Chlornitromycin (TN); Chloro-25 vetag; Chloromycetin (TN); Chlorsig (TN); Cloramfenicol [INN-Spanish]; D-Chloramphenicol; Dispersadron C (TN); Econochlor (TN); Elase-Chloromycetin; Fenicol (TN); Golden Eye (TN); Isoptophenicol (TN); Kemicetine (TN); Laevomycetin (TN); Medicom (TN); Mychel-Vet; Nevimycin (TN); Oftan Chlora (TN); Optrex Infected Eyes (TN); Orchadexoline (TN); Phenicol (TN); Renicol (TN); Silmycetin (TN); Sno-Phenicol; Synthomycine (TN); Tea-Cetin; Tega-Cetin; Tifomycine (TN); U-6062; Vernacetin (TN); Veticol (TN); C.A.F; CHLOROPTIC S.O.P; Chloramphenicol [INN:BAN:JAN]; Chloromycetin® D-threo-Chloramphenicol; Alficetyn, Chlornitromycin, Chloromycetin, Chloramphenicol; Chloramphenicol (JP15/USP/INN); Chloroptic S.O.P.; D(-)-threo-Chloramphenicol; D-(-)-Chloramphenicol; D-(-)-threo-Chloramphenicol; D(-)-threo-2-dichloroacetamido-1-p-nitrophen yl-propanediol; D(-)-threo-2-dichloroacetamido-1-p-nitrophenyl-propanediol
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  Disease Class 1A00-1C4Z: Bacterial infection
  Therapeutic Class Antibiotics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C11H12Cl2N2O5
  InChI 1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
  InChIKey WIIZWVCIJKGZOK-RKDXNWHRSA-N
  Canonical SMILES C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]
  External Link
Pubchem ID 5959
CAS Number 56-75-7
CHEBI ID 17698
TTD ID D0X6IU
INTEDE ID DR0298
VARIDT ID DR00989

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
BM017  CYP450 enzyme inhibition
BM043  Additive immunosuppressive effects
  Relation Graph
 Full list of drugs interacting with Chloramphenicol (ophthalmic)
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0621
 
Ethotoin
 
C11H12N2O2
 
3292 
Moderate    Inter Info   
[4], [5], [6]
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  80
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0030
 
Aldesleukin
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0114
 
Asparaginase Escherichia coli
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0190
 
Bleomycin
 
C55H84N17O21S3+
 
5360373 
Moderate    Inter Info   
[1], [2], [3]
D0264
 
Carmustine
 
C5H9Cl2N3O2
 
2578 
Moderate    Inter Info   
[1], [2], [3]
D0312
 
Chlorambucil
 
C14H19Cl2NO2
 
2708 
Moderate    Inter Info   
[1], [2], [3]
D0027
 
Aflibercept
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0048
 
Altretamine
 
C9H18N6
 
2123 
Moderate    Inter Info   
[1], [2], [3]
D0132
 
Axicabtagene ciloleucel
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0134
 
Azacitidine
 
C8H12N4O5
 
9444 
Moderate    Inter Info   
[1], [2], [3]
D0150
 
Belantamab mafodotin
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0153
 
Belinostat
 
C15H14N2O4S
 
6918638 
Moderate    Inter Info   
[1], [2], [3]
D0157
 
Bendamustine
 
C16H21Cl2N3O2
 
65628 
Moderate    Inter Info   
[1], [2], [3]
D0191
 
Blinatumomab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0203
 
Brexucabtagene autoleucel
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0223
 
Busulfan
 
C6H14O6S2
 
2478 
Moderate    Inter Info   
[1], [2], [3]
D0249
 
Capecitabine
 
C15H22FN3O6
 
60953 
Moderate    Inter Info   
[1], [2], [3]
D0357
 
Clofarabine
 
C10H11ClFN5O3
 
119182 
Moderate    Inter Info   
[1], [2], [3]
D0404
 
Cytarabine
 
C9H13N3O5
 
6253 
Moderate    Inter Info   
[1], [2], [3]
D0407
 
Dacarbazine
 
C6H10N6O
 
135398738 
Moderate    Inter Info   
[1], [2], [3]
D0410
 
Dactinomycin
 
C62H86N12O16
 
457193 
Moderate    Inter Info   
[1], [2], [3]
D0422
 
Daratumumab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0429
 
Daunorubicin
 
C27H29NO10
 
30323 
Moderate    Inter Info   
[1], [2], [3]
D0528
 
Doxorubicin
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[1], [2], [3]
D0529
 
Doxorubicin (liposomal)
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[1], [2], [3]
D0675
 
Fluorouracil
 
C4H3FN2O2
 
3385 
Moderate    Inter Info   
[1], [2], [3]
D0788
 
Idarubicin
 
C26H27NO9
 
42890 
Moderate    Inter Info   
[1], [2], [3]
D0790
 
Ifosfamide
 
C7H15Cl2N2O2P
 
3690 
Moderate    Inter Info   
[1], [2], [3]
D0806
 
Inotuzumab ozogamicin
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0829
 
Iobenguane (I-131)
 
C8H10IN3
 
60860 
Moderate    Inter Info   
[1], [2], [3]
D0851
 
Isatuximab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0902
 
Lenalidomide
 
C13H13N3O3
 
216326 
Moderate    Inter Info   
[1], [2], [3]
D0910
 
Levamisole
 
C11H12N2S
 
26879 
Moderate    Inter Info   
[1], [2], [3]
D0945
 
Lomustine
 
C9H16ClN3O2
 
3950 
Moderate    Inter Info   
[1], [2], [3]
D0962
 
Lurbinectedin
 
C41H44N4O10S
 
57327016 
Moderate    Inter Info   
[1], [2], [3]
D0964
 
Lutetium Lu 177 dotatate
 
C65H87LuN14O19S2
 
76966897 
Moderate    Inter Info   
[1], [2], [3]
D0986
 
Mechlorethamine
 
C5H11Cl2N
 
4033 
Moderate    Inter Info   
[1], [2], [3]
D0996
 
Melphalan
 
C13H18Cl2N2O2
 
460612 
Moderate    Inter Info   
[1], [2], [3]
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[1], [2], [3]
D1079
 
Mitoxantrone
 
C22H28N4O6
 
4212 
Moderate    Inter Info   
[1], [2], [3]
D1083
 
Mogamulizumab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1113
 
Naxitamab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1140
 
Niraparib
 
C19H20N4O
 
24958200 
Moderate    Inter Info   
[1], [2], [3]
D1161
 
Obinutuzumab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1164
 
Ofatumumab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1241
 
Pemetrexed
 
C20H21N5O6
 
135410875 
Moderate    Inter Info   
[1], [2], [3]
D1250
 
Pentostatin
 
C11H16N4O4
 
439693 
Moderate    Inter Info   
[1], [2], [3]
D1305
 
Plicamycin
 
C52H76O24
 
163659 
Moderate    Inter Info   
[1], [2], [3]
D1323
 
Pralatrexate
 
C23H23N7O5
 
148121 
Moderate    Inter Info   
[1], [2], [3]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Moderate    Inter Info   
[1], [2], [3]
D1424
 
Romidepsin
 
C24H36N4O6S2
 
5352062 
Moderate    Inter Info   
[1], [2], [3]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[1], [2], [3]
D1447
 
Sarilumab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1448
 
Satralizumab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1458
 
Selinexor
 
C17H11F6N7O
 
71481097 
Moderate    Inter Info   
[1], [2], [3]
D1476
 
Sirolimus
 
C51H79NO13
 
5284616 
Moderate    Inter Info   
[1], [2], [3]
D1529
 
Tafasitamab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1532
 
Talazoparib
 
C19H14F2N6O
 
135565082 
Moderate    Inter Info   
[1], [2], [3]
D1548
 
Temozolomide
 
C6H6N6O2
 
5394 
Moderate    Inter Info   
[1], [2], [3]
D1575
 
Thiotepa
 
C6H12N3PS
 
5453 
Moderate    Inter Info   
[1], [2], [3]
D1594
 
Tisagenlecleucel
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1610
 
Topotecan
 
C23H23N3O5
 
60700 
Moderate    Inter Info   
[1], [2], [3]
D1622
 
Trastuzumab deruxtecan
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1646
 
Trimetrexate
 
C19H23N5O3
 
5583 
Moderate    Inter Info   
[1], [2], [3]
D1667
 
Uracil mustard
 
C8H11Cl2N3O2
 
6194 
Moderate    Inter Info   
[1], [2], [3]
D1720
 
Zidovudine
 
C10H13N5O4
 
35370 
Moderate    Inter Info   
[1], [2], [3]
D0442
 
Denileukin diftitox
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0584
 
Epirubicin
 
C27H29NO11
 
41867 
Moderate    Inter Info   
[1], [2], [3]
D0666
 
Floxuridine
 
C9H11FN2O5
 
5790 
Moderate    Inter Info   
[1], [2], [3]
D0714
 
Gemcitabine
 
C9H11F2N3O4
 
60750 
Moderate    Inter Info   
[1], [2], [3]
D0717
 
Gemtuzumab ozogamicin
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0784
 
Ibritumomab tiuxetan
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0828
 
Interferon gamma-1b
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1077
 
Mitomycin
 
C15H18N4O5
 
5746 
Moderate    Inter Info   
[1], [2], [3]
D1416
 
Rituximab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1508
 
Streptozocin
 
C8H15N3O7
 
29327 
Moderate    Inter Info   
[1], [2], [3]
D1589
 
Tioguanine
 
C5H5N5S
 
2723601 
Moderate    Inter Info   
[1], [2], [3]
D1613
 
Tositumomab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1614
 
Tositumomab (I-131)
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1621
 
Trastuzumab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1639
 
Trifluridine
 
C10H11F3N2O5
 
6256 
Moderate    Inter Info   
[1], [2], [3]
References
1 Cerner Multum, Inc. "Australian Product Information.".
2 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3 Sim SM, Back DJ, Breckenridge AM "The effect of various drugs on the glucuronidation of zidovudine (azidothymidine AZT) by human liver microsomes." Br J Clin Pharmacol 32 (1991): 17-21. [PMID: 1909542]
4 Harper JM, Yost RL, Stewart RB, Ciezkowski J "Phenytoin-chloramphenicol interaction: a retrospective study." Drug Intell Clin Pharm 13 (1979): 425-9.
5 Krasinski K, Kusmiesz H, Nelson JD "Pharmacologic interactions among chloramphenicol, phenytoin and phenobarbital." Pediatr Infect Dis 1 (1982): 232-5. [PMID: 7177912]
6 Saltiel M, Stephens NM "Phenytoin-chloramphenicol interaction." Drug Intell Clin Pharm 14 (1980): 221.