Details of Drug-Drug Interaction
| Drug General Information (ID: DDIAGBJL0T) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Methadone | Drug Info | Didanosine | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Analgesics | Anti-Hiv Agents | |||||||
| Structure | |||||||||
| Mechanism of Methadone-Didanosine Interaction (Severity Level: Major) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph | |||||||||
| Drug Name | Methadone | Didanosine | |||||||
| Mechanism | Delay absorption and bioavailability of didanosine | Didanosine | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Adverse reactions | ||||||||
| Factor Description | An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, didanosine pediatric powder should not be prescribed in combination with methadone. If coadministration of didanosine and methadone is necessary, the recommended formulation of didanosine is the enteric-coated, delayed-release formulation (Videx EC). Patients should be closely monitored for adequate clinical response when Videx EC is coadministered with methadone, including monitoring for changes in viral load. | ||||||||