Drug General Information (ID: DDIAC23E1Y)
Drug Name			Digitoxin		Drug Info		Calcium carbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Antacids/Minerals And Electrolytes
Structure

Mechanism of Digitoxin-Calcium carbonate Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Digitoxin				Calcium carbonate
Mechanism		Digitalis glycosides				Potentiate the risk of digitalis toxicity
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Digitoxin and Calcium carbonate

Recommended Action
Management		Caution is advised if calcium preparations are used in patients receiving digitalis glycosides. Patients should be advised not to exceed the calcium dosage prescribed for them and to consult their healthcare provider before consuming additional products that may contain substantial amounts of calcium (e.g., over-the-counter supplements).

References
1	Davies NT "Anti-nutrient factors affecting mineral utilization." Proc Nutr Soc 38 (1979): 121-8. [PMID: 88737]
2	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
3	Product Information. PhosLo (calcium acetate) Braintree, Braintree, MA.