Details of Drug-Drug Interaction
| Drug General Information (ID: DDI9M4PQUO) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Sulfisoxazole | Drug Info | Tolazamide | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antiinfective Agents | Antidiabetic Agents | |||||||
| Structure | |||||||||
| Mechanism of Sulfisoxazole-Tolazamide Interaction (Severity Level: Moderate) | |||||||||
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| Increased risk of hypoglycemia Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Sulfisoxazole | Tolazamide | |||||||
| Mechanism | Hypoglycemic effects | Hypoglycemic effects | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Hypoglycemia | ||||||||
| Factor Description | Hypoglycemia is a condition in which your blood sugar (glucose) level is below the standard range. It causes irregular or rapid heartbeat, pale skin, numbness of the lips, tongue or cheeks, and sweating. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Close monitoring for the development of hypoglycemia is recommended if these drugs are coadministered with insulin secretagogues, particularly in patients with advanced age and/or renal impairment. The oral antidiabetic dosage(s) may require adjustment if an interaction is suspected. Patients should be apprised of the signs and symptoms of hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, hunger, tremor, weakness, sweating, palpitations), how to treat it, and to contact their doctor if it occurs. Patients should be observed for loss of glycemic control when these drugs are withdrawn. | ||||||||