Drug General Information (ID: DDI9I5X4MC)
Drug Name			Sucralfate		Drug Info		Levothyroxine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gi Agents				Antithyroid Agents
Structure

Mechanism of Sucralfate-Levothyroxine Interaction (Severity Level: Minor)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Sucralfate				Levothyroxine
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Sucralfate due to formation of complexes caused by Levothyroxine

References
1	Havrankova J, Lahaie R "Levothyroxine binding by sucralfate." Ann Intern Med 117 (1992): 445-6. [PMID: 1503346]
2	Khan F, Jeanniton E, Renedo M "Does sucralfate impede levothyroxine therapy?" Ann Intern Med 118 (1993): 317. [PMID: 8481187]