Drug General Information (ID: DDI9FBSOIP)
Drug Name			Lamivudine		Drug Info		Sorbitol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Laxatives
Structure

Mechanism of Lamivudine-Sorbitol Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Lamivudine				Sorbitol
Mechanism		Lamivudine				Reduce the therapeutic efficacy of lamivudine
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Lamivudine when combined with Sorbitol

Recommended Action
Management		When possible, avoid use of lamivudine with products that contain osmotic polyalcohols (e.g., sorbitol) or monosaccharide alcohols (e.g., lactitol, mannitol). If coadministration cannot be avoided, more frequent monitoring of viral load should be considered.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Adkison K, Wolstenholme A, Lou Y, et al. "Effect of Sorbitol on the Pharmacokinetic Profile of Lamivudine Oral Solution in Adults: An Open-label, Randomized Study." Clin Pharmacol Ther (2017):. [PMID: 29150845]