Drug General Information (ID: DDI9D0X3JC)
  Drug Name Ethanol Drug Info Opium Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Analgesics Narcotic Analgesics

 Mechanism of Ethanol-Opium Interaction (Severity Level: Moderate)
     Additive CNS depression effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Ethanol Opium
      Mechanism CNS depression effects CNS depression effects
      Key Mechanism Factor 1
Factor Name CNS depression effects
Factor Description CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
      Mechanism Description
  • Additive CNS depression effects by the combination of Ethanol and Opium 

Recommended Action
      Management Concomitant use of opioid analgesics with ethanol should be avoided.

References
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8 Girre C, Hirschhorn M, Bertaux L, et al "Enhancement of propoxyphene bioavailability by ethanol: relation to psychomotor and cognitive function in healthy volunteers." Eur J Clin Pharmacol 41 (1991): 147-52. [PMID: 1743247]
9 Linnoila M, Hakkinen S "Effects of diazepam and codeine, alone and in combination with alcohol, on simulated driving." Clin Pharmacol Ther 15 (1974): 368-73. [PMID: 4595291]