Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDI8SJPEAG)
  Drug Name Memantine Drug Info Opicapone Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Cholinesterase Inhibitors Dopaminergic Antiparkinsonism Agents
  Structure

 Mechanism of Memantine-Opicapone Interaction (Severity Level: Minor)
     Additive dopaminergic effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Memantine Opicapone
      Mechanism Dopaminergic effects
Dopamine receptor  Agonist 		Dopaminergic effects
Catechol-O-methyl-transferase  Inhibitor
      Key Mechanism Factor 1
Factor Name Dopamine receptor Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
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      Key Mechanism Factor 2
Factor Name Catechol-O-methyl-transferase
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Structure Sequence
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
Gene Name COMT
Uniprot ID COMT_HUMAN
KEGG Pathway hsa:1312
Protein Family Class I-like SAM-binding methyltransferase superfamily
Protein Function
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
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      Mechanism Description
  • Additive dopaminergic effects by the combination of Memantine and Opicapone 

References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 Multum Information Services, Inc. Expert Review Panel.