Details of Drug-Drug Interaction
| Drug General Information (ID: DDI8FVN7PD) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Phenytoin | Drug Info | Sucralfate | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Anticonvulsants | Gi Agents | |||||||
| Structure | |||||||||
| Mechanism of Phenytoin-Sucralfate Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Complex formation Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Phenytoin | Sucralfate | |||||||
| Mechanism | Binds to polyvalent cations | Polyvalent cations | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Chelation | ||||||||
| Factor Description | Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | Patients should be advised to take phenytoin at least two hours before or 6 hours after sucralfate and to notify their physician if loss of seizure control occurs. | ||||||||