Drug General Information (ID: DDI8EK72HU)
Drug Name			Indinavir		Drug Info		Didanosine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Anti-Hiv Agents
Structure

Mechanism of Indinavir-Didanosine Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Indinavir				Didanosine
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Indinavir due to altered gastric pH caused by Didanosine

Recommended Action
Management		If concomitant therapy is desired, the two medications should be taken at least one hour apart on an empty stomach.

References
1	Product Information. Videx (didanosine). Bristol-Myers Squibb, Princeton, NJ.