Drug General Information (ID: DDI83U1VN5)
Drug Name			Metipranolol (ophthalmic)		Drug Info		Methacholine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Bronchodilators
Structure

Mechanism of Metipranolol (ophthalmic)-Methacholine Interaction (Severity Level: Major)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Metipranolol (ophthalmic)				Methacholine
Mechanism		Enhance or prolong the bronchoconstrictive effect of methacholine				Methacholine
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Methacholine and Metipranolol (ophthalmic)

Recommended Action
Management		Administration of methacholine to a patient on any beta blocker therapy is considered contraindicated.

References
1	Product Information. Provocholine (methacholine). Methapharm Inc, Brantford, ON.