Details of Drug

Details of Drug

 Drug General Information (ID: D1016)
  Drug Name
Methacholine
  Drug Type Small molecule
  Drug Synonymous
methacholine; Acetylmethylcholine; beta-Methylacetylcholine; Provocholine; 55-92-5; Acetyl-beta-methylcholine; MCH; Mecholin; CHEBI:6804; Methacholin; Mecholin; Mecholine; Methacholinum; UNII-03V657ZD3V; Choline, acetyl-beta-methyl-; BRN 1769932; Methacholine ion; Methacholine cation; 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; 03V657ZD3V; Prestwick0_000759; Prestwick1_000759; Prestwick2_000759; Prestwick3_000759; CHEMBL978; cid_6114; Lopac0_000025; SCHEMBL69103; BSPBio_000778; BSPBio_001985; SPBio_002717; BPBio1_000856; GTPL7438; DTXSID2046967; BDBM48918; 2-acetyloxypropyl-trimethylazanium; AMMONIUM, (2-HYDROXYPROPYL)TRIMETHYL-, ACETATE (ESTER); PDSP1_000136; PDSP2_000135; [2-(acetyloxy)propyl]trimethylazanium; CCG-204121; DB06709; MCULE-6246299571; NCGC00015045-03; NCGC00015045-04; NCGC00015045-06; NCGC00015045-13; NCGC00089798-02; 2-acetoxypropyl(trimethyl)ammonium;chloride; SBI-0050014.P003; 2-acetyloxy-N,N,N-trimethylpropan-1-aminium; 2-acetyloxypropyl(trimethyl)ammonium;chloride; C07471; Q413188
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  Therapeutic Class Bronchodilators
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C8H18NO2+
  InChI InChI=1S/C8H18NO2/c1-7(11-8(2)10)6-9(3,4)5/h7H,6H2,1-5H3/q+1
  InChIKey NZWOPGCLSHLLPA-UHFFFAOYSA-N
  Canonical SMILES CC(C[N+](C)(C)C)OC(=O)C
  External Link
Pubchem ID 1993

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM006  Pharmacodynamic additive effects
BM009  Altered absorption (Unspecific)
BM037  Additive cholinergic effects
BM083  Potentiated the pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Methacholine
      Affected gastrointestinal absorption
   Altered absorption (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0814
 
Insulin human (inhalation, rapid acting)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[2], [3], [4]
      Pharmacodynamic additive effects
   Additive cholinergic effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0054
 
Amifampridine
 
C5H7N3
 
5918 
Moderate    Inter Info   
[5], [6]
   Potentiated the pharmacological effects (Unspecific) Drug Num:  18
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0010
 
Acebutolol
 
C18H28N2O4
 
1978 
Major    Inter Info   
[1]
D0117
 
Atenolol
 
C14H22N2O3
 
2249 
Major    Inter Info   
[1]
D0173
 
Betaxolol
 
C18H29NO3
 
2369 
Major    Inter Info   
[1]
D0174
 
Betaxolol (ophthalmic)
 
C18H29NO3
 
2369 
Major    Inter Info   
[1]
D0188
 
Bisoprolol
 
C18H31NO4
 
2405 
Major    Inter Info   
[1]
D0266
 
Carteolol (ophthalmic)
 
C16H24N2O3
 
2583 
Major    Inter Info   
[1]
D0267
 
Carvedilol
 
C24H26N2O4
 
2585 
Major    Inter Info   
[1]
D0602
 
Esmolol
 
C16H25NO4
 
59768 
Major    Inter Info   
[1]
D0884
 
Labetalol
 
C19H24N2O3
 
3869 
Major    Inter Info   
[1]
D0915
 
Levobunolol (ophthalmic)
 
C17H25NO3
 
39468 
Major    Inter Info   
[1]
D1045
 
Metipranolol (ophthalmic)
 
C17H27NO4
 
31477 
Major    Inter Info   
[1]
D1049
 
Metoprolol
 
C15H25NO3
 
4171 
Major    Inter Info   
[1]
D1098
 
Nadolol
 
C17H27NO4
 
39147 
Major    Inter Info   
[1]
D1293
 
Pindolol
 
C14H20N2O2
 
4828 
Major    Inter Info   
[1]
D1357
 
Propranolol
 
C16H21NO2
 
4946 
Major    Inter Info   
[1]
D1498
 
Sotalol
 
C12H20N2O3S
 
5253 
Major    Inter Info   
[1]
D1585
 
Timolol
 
C13H24N4O3S
 
33624 
Major    Inter Info   
[1]
D1586
 
Timolol (ophthalmic)
 
C13H24N4O3S
 
33624 
Major    Inter Info   
[1]
References
1 Product Information. Provocholine (methacholine). Methapharm Inc, Brantford, ON.
2 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3 Jerntorp P, Almer LO "Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy in non-insulin dependent diabetes." Acta Med Scand 656 (1981): 33-6. [PMID: 6953748]
4 Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
5 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
6 Product Information. Firdapse (amifampridine). Catalyst Pharmaceuticals, Inc., Coral Gables, FL.