| Mechanism of Memantine-Potassium citrate Interaction
(Severity Level: Minor)
|
|
Altered urine pH
Click to Show/Hide Mechanism Graph
|
 |
| Drug Name |
Memantine |
Potassium citrate |
|
Mechanism
|
Urine pH sensitive |
Urine alkalinizer
Decrease the renal excretion
|
| Key Mechanism Factor 1 |
| Factor Name |
Urine pH |
| Factor Description |
The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion. |
| Mechanism Description |
- Altered elimination of Memantine caused by Potassium citrate mediated altered urine pH
|
