Drug General Information (ID: DDI7T61SDM)
  Drug Name Diflunisal Drug Info Kaolin Drug Info
  Drug Type Small molecule Natural product
  Therapeutic Class Analgesics Herbal Products
  Structure

 Mechanism of Diflunisal-Kaolin Interaction (Severity Level: Minor)
     Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Diflunisal Kaolin
      Mechanism Diflunisal Decrease the bioavailability of diflunisal
      Key Mechanism Factor 1
Factor Name Pharmacokinetic
Factor Description Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Altered absorption of Diflunisal caused by Kaolin 

References
1 D'Arcy PF, McElnay JC "Drug-antacid interactions: assessment of clinical importance." Drug Intell Clin Pharm 21 (1987): 607-17. [PMID: 2886325]
2 Product Information. Dolobid (diflunisal). Merck & Co, Inc, West Point, PA.
3 Verbeeck R, Tjandramaga TB, Mullie A, Verbesselt R, de Schepper PJ "Effect of aluminum hydroxide on diflunisal absorption." Br J Clin Pharmacol 7 (1979): 519-22. [PMID: 314299]