Drug General Information (ID: DDI7CPO13Y)
Drug Name			Smallpox (Vaccinia) Vaccine, Live		Drug Info		Emapalumab		Drug Info
Drug Type		Vaccine				Monoclonal antibody
Therapeutic Class		Vaccine				Selective Immunosuppressants

Mechanism of Smallpox (Vaccinia) Vaccine, Live-Emapalumab Interaction (Severity Level: Major)
Antagonize the effect of vaccine/toxoid Click to Show/Hide Mechanism Graph
Drug Name		Smallpox (Vaccinia) Vaccine, Live				Emapalumab
Mechanism		Vaccine or toxoid				Immunosuppressive effects
Key Mechanism Factor 1
		Factor Name		Vaccine/toxoid
		Factor Description		The beneficial effects of the vaccine/toxinoid may be reduced, leading to a diminished or suboptimal immune response.
Mechanism Description		Antagonize the effect of Smallpox (Vaccinia) Vaccine, Live when combined with Emapalumab

Recommended Action
Management		The use of live or live attenuated vaccines should be avoided during and for at least 4 weeks after the last dose of emapalumab.

References
1	Product Information. Gamifant (emapalumab). Sobi Inc, Ardmore, PA.