Details of Drug

Details of Drug

 Drug General Information (ID: D0564)
  Drug Name
Emapalumab
  Drug Type Monoclonal antibody
  Drug Synonymous
emapalumab; Emapalumab [INN]; Emapalumab [USAN:INN]; UNII-3S252O2Z4X; 3S252O2Z4X
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  Disease Class 4A01: Adaptive immunity immunodeficiency
  Therapeutic Class Selective Immunosuppressants
  External Link
TTD ID D0UI7K

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM016  Altered formation of CYP450 enzymes
BM043  Additive immunosuppressive effects
BM100  Antagonize the effect of vaccine/toxoid
BM105  Antagonize the effect of probiotics
  Relation Graph
 Full list of drugs interacting with Emapalumab
      Affected intra/extra-hepatic metabolism
   Altered formation of CYP450 enzymes Drug Num:  59
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0045
 
Alprazolam
 
C17H13ClN4
 
2118 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0064
 
Aminophylline
 
C16H24N10O4
 
9433 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0069
 
Amlodipine
 
C20H25ClN2O5
 
2162 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0096
 
Apixaban
 
C25H25N5O4
 
10182969 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0120
 
Atorvastatin
 
C33H35FN2O5
 
60823 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0219
 
Buprenorphine
 
C29H41NO4
 
644073 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0356
 
Clobazam
 
C16H13ClN2O2
 
2789 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0362
 
Clonazepam
 
C15H10ClN3O3
 
2802 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0473
 
Diazepam
 
C16H13ClN2O
 
3016 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Moderate    Inter Info   
[7], [8], [13]
D0485
 
Dienogest
 
C20H25NO2
 
68861 
Moderate    Inter Info   
[7], [8], [13]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0536
 
Drospirenone
 
C24H30O3
 
68873 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0161
 
Benzhydrocodone
 
C25H25NO4
 
49836084 
Moderate    Inter Info   
[7], [8], [13]
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Moderate    Inter Info   
[7], [8], [13]
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Moderate    Inter Info   
[7], [8], [13]
D0620
 
Ethosuximide
 
C7H11NO2
 
3291 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0626
 
Etonogestrel
 
C22H28O2
 
6917715 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0640
 
Felodipine
 
C18H19Cl2NO4
 
3333 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0646
 
Fentanyl
 
C22H28N2O
 
3345 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0664
 
Flecainide
 
C17H20F6N2O3
 
3356 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0772
 
Hydrocodone
 
C18H21NO3
 
5284569 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0865
 
Isradipine
 
C19H21N3O5
 
3784 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0911
 
Levamlodipine
 
C20H25ClN2O5
 
9822750 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0922
 
Levonorgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0927
 
Lidocaine
 
C14H22N2O
 
3676 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0956
 
Lovastatin
 
C24H36O5
 
53232 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0990
 
Medroxyprogesterone acetate
 
C24H34O4
 
6279 
Moderate    Inter Info   
[7], [8], [13]
D1003
 
Mephenytoin
 
C12H14N2O2
 
4060 
Moderate    Inter Info   
[7], [8], [13]
D1011
 
Mestranol
 
C21H26O2
 
6291 
Moderate    Inter Info   
[7], [8], [13]
D1017
 
Methadone
 
C21H27NO
 
4095 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1040
 
Methylphenobarbital
 
C13H14N2O3
 
8271 
Moderate    Inter Info   
[7], [8], [13]
D1054
 
Mexiletine
 
C11H17NO
 
4178 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1060
 
Midazolam
 
C18H13ClFN3
 
4192 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1130
 
Nicardipine
 
C26H29N3O6
 
4474 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1134
 
Nifedipine
 
C17H18N2O6
 
4485 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1138
 
Nimodipine
 
C21H26N2O7
 
4497 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1141
 
Nisoldipine
 
C20H24N2O6
 
4499 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1154
 
Norethisterone
 
C20H26O2
 
6230 
Moderate    Inter Info   
[7], [8], [13]
D1156
 
Norgestimate
 
C23H31NO3
 
6540478 
Moderate    Inter Info   
[7], [8], [13]
D1157
 
Norgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[7], [8], [13]
D1201
 
Oxtriphylline
 
C12H21N5O3
 
656652 
Moderate    Inter Info   
[7], [8], [13]
D1203
 
Oxycodone
 
C18H21NO4
 
5284603 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1343
 
Procainamide
 
C13H21N3O
 
4913 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1353
 
Propafenone
 
C21H27NO3
 
4932 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1417
 
Rivaroxaban
 
C19H18ClN3O5S
 
9875401 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1473
 
Simvastatin
 
C25H38O5
 
54454 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1512
 
Sufentanil
 
C22H30N2O2S
 
41693 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1570
 
Theophylline
 
C7H8N4O2
 
2153 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1632
 
Triazolam
 
C17H12Cl2N4
 
5556 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1688
 
Venetoclax
 
C45H50ClN7O7S
 
49846579 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [1], [8], [9], [10], [11], [12], [13], [14], [15], [16]
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0499
 
Dimethyl fumarate
 
C6H8O4
 
637568 
Moderate    Inter Info   
[20]
D0507
 
Diroximel fumarate
 
C11H13NO6
 
73330464 
Moderate    Inter Info   
[20]
D1085
 
Monomethyl fumarate
 
C5H6O4
 
5369209 
Moderate    Inter Info   
[20]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  12
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1744
 
Bacillus calmette-guerin substrain tice live antigen
 
NA
 
NA
Major    Inter Info   
[1]
D1808
 
Human adenovirus e serotype 4 strain cl-68578 antigen
 
NA
 
NA
Major    Inter Info   
[1]
D1839
 
Measles virus vaccine live attenuated
 
NA
 
NA
Major    Inter Info   
[1]
D1849
 
Mumps virus strain B level jeryl lynn live antigen
 
NA
 
NA
Major    Inter Info   
[1]
D1881
 
Rotavirus vaccine
 
NA
 
NA
Major    Inter Info   
[1]
D1882
 
Rubella virus vaccine
 
NA
 
NA
Major    Inter Info   
[1]
D1890
 
Smallpox (Vaccinia) Vaccine, Live
 
NA
 
NA
Major    Inter Info   
[1]
D1897
 
Talimogene laherparepvec
 
NA
 
NA
Major    Inter Info   
[2]
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[1]
D1920
 
Varicella Zoster Vaccine (Recombinant)
 
NA
 
NA
Major    Inter Info   
[1]
D1693
 
Vibrio cholerae CVD 103-HgR strain live antigen (live)
 
NA
 
NA
Major    Inter Info   
[1]
D1922
 
Yellow Fever Vaccine
 
NA
 
NA
Major    Inter Info   
[1]
   Antagonize the effect of probiotics Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1749
 
Bifidobacterium longum infantis
 
NA
 
NA
Moderate    Inter Info   
[17], [18], [19]
D1827
 
Lactobacillus acidophilus
 
NA
 
NA
Moderate    Inter Info   
[17], [18], [19]
References
1 Product Information. Gamifant (emapalumab). Sobi Inc, Ardmore, PA.
2 Product Information. Imlygic (talimogene laherparepvec). Amgen USA, Thousand Oaks, CA.
3 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
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5 Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
6 Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
7 Product Information. Cosentyx (secukinumab). Novartis Pharmaceuticals, East Hanover, NJ.
8 Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
9 Product Information. Ilumya (tildrakizumab). Merck & Company Inc, Whitehouse Station, NJ.
10 Product Information. Kevzara (sarilumab). sanofi-aventis, Bridgewater, NJ.
11 Product Information. Remicade (infliximab). Centocor Inc, Malvern, PA.
12 Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.
13 Product Information. Skyrizi (risankizumab). AbbVie US LLC, North Chicago, IL.
14 Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
15 Product Information. Sylvant (siltuximab). Janssen Biotech, Inc., Horsham, PA, PA.
16 Product Information. Taltz Autoinjector (ixekizumab). Eli Lilly and Company, Indianapolis, IN.
17 Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
18 Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
19 Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]
20 Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.