Drug General Information (ID: DDI6X39E7U)
Drug Name			Benzthiazide		Drug Info		Ginkgo biloba		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Antihypertensive Agents				Herbal Products

Mechanism of Benzthiazide-Ginkgo biloba Interaction (Severity Level: Moderate)
Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Drug Name		Benzthiazide				Ginkgo biloba
Mechanism		Thiazide diuretic				Reduce the antihypertensive effect of thiazide diuretic
Key Mechanism Factor 1
		Factor Name		Antihypertensive agents
		Factor Description		The hypotensive effect of antihypertensive agents may be reduced, leading to higher blood pressure, increased blood pressure fluctuations, and possible cardiovascular damage.
Mechanism Description		Antagonize the effect of Benzthiazide when combined with Ginkgo biloba

Recommended Action
Management		In general, patients should consult a healthcare provider before taking any herbal or alternative medicine. Caution may be appropriate when combining ginkgo products with thiazide diuretics, especially in the elderly. Blood pressure should be monitored regularly.

References
1	Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75. [PMID: 11772128]