Drug General Information (ID: DDI6DYSAI7)
  Drug Name Glipizide Drug Info Safinamide Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antidiabetic Agents Dopaminergic Antiparkinsonism Agents
  Structure

 Mechanism of Glipizide-Safinamide Interaction (Severity Level: Moderate)
     Increased risk of hypoglycemia Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Glipizide Safinamide
      Mechanism Hypoglycemic effects Hypoglycemic effects
      Key Mechanism Factor 1
Factor Name Hypoglycemia
Factor Description Hypoglycemia is a condition in which your blood sugar (glucose) level is below the standard range. It causes irregular or rapid heartbeat, pale skin, numbness of the lips, tongue or cheeks, and sweating.
      Mechanism Description
  • Increased risk of hypoglycemia by the combination of Glipizide and Safinamide 

Recommended Action
      Management Close monitoring for the development of hypoglycemia is recommended if these drugs are coadministered with insulin secretagogues, particularly in patients with advanced age and/or renal impairment. The oral antidiabetic dosage(s) may require adjustment if an interaction is suspected. Patients should be apprised of the signs and symptoms of hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, hunger, tremor, weakness, sweating, palpitations), how to treat it, and to contact their doctor if it occurs. Patients should be observed for loss of glycemic control when these drugs are withdrawn.

References
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64 Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
65 Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
66 Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
67 Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
68 Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
69 Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
70 Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
71 Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
72 Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
73 Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
74 Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
75 Product Information. Tolinase (tolazamide) Pharmacia and Upjohn, Kalamazoo, MI.
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