Drug General Information (ID: DDI6850EN2)
Drug Name			Hydrocortisone		Drug Info		Calcium carbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Antacids/Minerals And Electrolytes
Structure

Mechanism of Hydrocortisone-Calcium carbonate Interaction (Severity Level: Minor)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Hydrocortisone				Calcium carbonate
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Hydrocortisone due to altered gastric pH caused by Calcium carbonate

References
1	Albin H, Vincon G, Demotes-Mainard F, et al "Effect of aluminium phosphate on the bioavailability of cimetidine and prednisolone." Eur J Clin Pharmacol 26 (1984): 271-3. [PMID: 6723769]
2	Naggar VF, Khalil SA, Gouda MW "Effect of concomitant administration of magnesium trisilicate on GI absorption of dexamethasone in humans." J Pharm Sci 67 (1978): 1029-30. [PMID: 207854]
3	Tanner AR, Caffin JA, Halliday JW, Powell LW "Concurrent administration of antacids and prednisone: effect on serum levels of prednisolone." Br J Clin Pharmacol 7 (1979): 397-400. [PMID: 444359]