Drug General Information (ID: DDI5R9MF0B)
Drug Name			Morphine		Drug Info		Ethanol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Analgesics
Structure

Mechanism of Morphine-Ethanol Interaction (Severity Level: Major)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Morphine				Ethanol
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Morphine and Ethanol

Recommended Action
Management		Until more information is available, patients taking sustained-release formulations of morphine should not consume alcohol or use medications that contain alcohol. In general, potent narcotics such as morphine should not be combined with alcohol.

References
1	Product Information. Avinza (morphine). Ligand Pharmaceuticals, San Diego, CA.
2	Ghalie R "Dear Health Care Professional. AVINZA_DHCP_Letter_Oct2005.pdf.".