Details of Drug-Drug Interaction
| Drug General Information (ID: DDI5N9ZUSY) | |||||||||
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| Drug Name | Clofazimine | Drug Info | Picosulfuric acid | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antiinflammatory Agents | Vitamins | |||||||
| Structure | |||||||||
| Mechanism of Clofazimine-Picosulfuric acid Interaction (Severity Level: Moderate) | |||||||||
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| Altered intestinal flora Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Clofazimine | Picosulfuric acid | |||||||
| Mechanism 1 | Alters GI flora | Affected by alters GI flora | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Intestinal flora | ||||||||
| Factor Description | The intestinal flora has multiple effects on human health, and altering the intestinal microbiota can affect the absorption of drugs and alter their pharmacological effects. | ||||||||
| Mechanism Description |
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| Increased risk of ventricular arrhythmias Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Clofazimine | Picosulfuric acid | |||||||
| Mechanism 2 | Prolong QT interval | Electrolyte disturbances | |||||||
| Key Mechanism Factor 2 | |||||||||
| Factor Name | Ventricular arrhythmias | ||||||||
| Factor Description | Ventricular arrhythmias are abnormal heart rhythms that cause your heart's lower chambers to pump blood instead of pumping it. This can limit or stop your heart from supplying blood to your body. While some of these arrhythmias are harmless and do not cause symptoms, others can have serious, even fatal, effects on your body. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Consider use of an alternate laxative in patients who have recently taken or are currently taking an antibiotic. If concomitant use is required, additional bowel cleansing and colonoscopy may be required. The recommended dosage and duration of treatment with sodium picosulfate should not be exceeded. In addition, patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope. | ||||||||