Details of Drug-Drug Interaction
| Drug General Information (ID: DDI5KWVEAD) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Phenylbutazone | Drug Info | Tolazamide | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Analgesics | Antidiabetic Agents | |||||||
| Structure | |||||||||
| Mechanism of Phenylbutazone-Tolazamide Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph | |||||||||
| Drug Name | Phenylbutazone | Tolazamide | |||||||
| Mechanism 1 | Inhibition of sulfonylurea metabolism | Sulfonylurea | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Pharmacokinetics | ||||||||
| Factor Description | Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects. | ||||||||
| Mechanism Description |
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| Decreased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph | |||||||||
| Drug Name | Phenylbutazone | Tolazamide | |||||||
| Mechanism 2 | Inhibition of sulfonylurea renal clearance | Sulfonylurea | |||||||
| Key Mechanism Factor 2 | |||||||||
| Factor Name | Pharmacokinetics | ||||||||
| Factor Description | Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Patients receiving this combination should be monitored for increased hypoglycemic effects and advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations) and to notify their physician if it occurs. The sulfonylurea dosage may require reduction in affected patients. | ||||||||