Drug General Information (ID: DDI52VA0Y1)
Drug Name			Doxycycline		Drug Info		Sucralfate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Gi Agents
Structure

Mechanism of Doxycycline-Sucralfate Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Doxycycline				Sucralfate
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Sucralfate due to formation of complexes caused by Doxycycline

Recommended Action
Management		To minimize the potential for interaction, tetracyclines should be administered at least 2 hours before sucralfate.

References
1	Cerner Multum, Inc. "Canadian Product Information.".
2	McCarthy DM "Sucralfate." N Engl J Med 325 (1991): 1017-25. [PMID: 1886624]
3	Product Information. Carafate (sucralfate). Hoechst Marion-Roussel Inc, Kansas City, MO.