Details of Drug-Drug Interaction
| Drug General Information (ID: DDI50WQAND) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Ethanol | Drug Info | Milnacipran | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Analgesics | Antidepressants | |||||||
| Structure | |||||||||
| Mechanism of Ethanol-Milnacipran Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of hepatotoxicity Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Ethanol | Milnacipran | |||||||
| Mechanism | Hepatotoxicity | Hepatotoxicity | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Hepatotoxicity | ||||||||
| Factor Description | Combination of drugs that can induce hepatotoxicity may increase the risk of liver injury. Symptoms vary depending on the level of exposure and the total extent of liver damage, and may cause few symptoms if the damage is mild, and eventually lead to liver failure in patients with severe damage. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | Due to the risk of liver injury, milnacipran should generally not be prescribed to patients with substantial alcohol use. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO. | ||||||||||||||||||