Drug General Information (ID: DDI4WZ03GF)
Drug Name			Dexlansoprazole		Drug Info		Pexidartinib		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Proton Pump Inhibitors				Multikinase Inhibitors
Structure

Mechanism of Dexlansoprazole-Pexidartinib Interaction (Severity Level: Major)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Dexlansoprazole				Pexidartinib
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Pexidartinib due to altered gastric pH caused by Dexlansoprazole

Recommended Action
Management		Concomitant use of pexidartinib with proton pump inhibitors should be avoided. If acid-suppression therapy is required, pexidartinib may be administered 2 hours before or 2 hours after taking a locally-acting antacid, or if using an H2-receptor antagonist, administer pexidartinib at least 2 hours before or 10 hours after taking the H2-receptor antagonist.

References
1	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.