Details of Drug

Drug General Information (ID: D1258)
Drug Name	Pexidartinib
Drug Type	Small molecule
Drug Synonymous	PLX-3397 Click to Show/Hide
Disease Class	8A20: Alzheimer disease; FA2Z: Inflammatory arthropathy; LD2D: Phakomatoses/hamartoneoplastic syndrome; 2F7B: Bone/articular cartilage neoplasm
Therapeutic Class	Multikinase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C20H15ClF3N5
InChI	1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)
InChIKey	JGWRKYUXBBNENE-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F
External Link
	Pubchem ID	25151352
	CAS Number	1029044-16-3
	CHEBI ID	145373
	TTD ID	D09TAB
	INTEDE ID	DR1269

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM005 Altered gastric pH BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM055 Increased risk of hepatotoxicity
Relation Graph

Full list of drugs interacting with Pexidartinib
Affected gastrointestinal absorption
	Altered gastric pH					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Major		Inter Info	[1]
D0603		Esomeprazole	C17H19N3O3S	9568614	Major		Inter Info	[1]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Major		Inter Info	[1]
D1179		Omeprazole	C17H19N3O3S	4594	Major		Inter Info	[1]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Major		Inter Info	[1]
D1373		Rabeprazole	C18H21N3O3S	5029	Major		Inter Info	[1]
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[1]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[1]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[1]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[1]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[1]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[1]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[1]
D1151		Nizatidine	C12H21N5O2S2	3033637	Moderate		Inter Info	[1]
D1381		Ranitidine	C13H22N4O3S	3001055	Moderate		Inter Info	[1]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Moderate		Inter Info	[1]
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[1]
D1483		Sodium citrate	C6H5Na3O7	6224	Moderate		Inter Info	[1]
Affected cellular transport
	Transporter inhibition					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[6], [30], [31]
D0631		Ezetimibe	C24H21F2NO3	150311	Moderate		Inter Info	[166], [1]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[166], [1]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[166], [1]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[166], [1]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[166], [1]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[5], [6], [261]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 64
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1], [2]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[17], [18], [19]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1]
D0409		Dacomitinib	C24H25ClFN5O2	11511120	Major		Inter Info	[1], [2]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[1]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1], [2]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[1]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1]
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[1]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1]
D0891		Lanreotide	C54H69N11O10S2	71349	Major		Inter Info	[1]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[1]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[39]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[1]
D1057		Miconazole	C18H14Cl4N2O	4189	Major		Inter Info	[1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[1]
D1134		Nifedipine	C17H18N2O6	4485	Major		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[1]
D1163		Octreotide	C49H66N10O10S2	448601	Major		Inter Info	[1]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[1]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[1]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1341		Probenecid	C13H19NO4S	4911	Major		Inter Info	[1]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[1]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Major		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1], [2]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1], [2]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[66]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[84]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[104]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[105]
	CYP450 enzyme induction					Drug Num: 180
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[3], [4]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[5], [6], [7]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[8], [5], [6], [9], [10], [11], [12], [13], [14], [15]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[16]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[6], [20]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[6]
D0485		Dienogest	C20H25NO2	68861	Major		Inter Info	[1], [21], [22]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Major		Inter Info	[6], [23], [24]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[1]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[25]
D0619		Ethinylestradiol	C20H24O2	5991	Major		Inter Info	[1], [21], [22]
D0626		Etonogestrel	C22H28O2	6917715	Major		Inter Info	[1]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[8], [5], [6], [9], [10], [11], [12], [13], [14], [15]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[27], [28], [29]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[6], [32], [33]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[34], [35]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[34], [36]
D0922		Levonorgestrel	C21H28O2	13109	Major		Inter Info	[1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[34], [37]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[38]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Major		Inter Info	[1], [21], [22]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D1154		Norethisterone	C20H26O2	6230	Major		Inter Info	[1], [21], [22]
D1156		Norgestimate	C23H31NO3	6540478	Major		Inter Info	[1], [21], [22]
D1157		Norgestrel	C21H28O2	13109	Major		Inter Info	[1], [21], [22]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[5], [6], [52]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[6], [53]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[12], [13], [14]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[34], [54]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[34], [55]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[56]
D1336		Pretomanid	C14H12F3N3O5	456199	Major		Inter Info	[57]
D1407		Rimegepant	C28H28F2N6O3	51049968	Major		Inter Info	[58]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[59]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[5], [60]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[61]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[62], [63]
D1686		Velpatasvir	C49H54N8O8	67683363	Major		Inter Info	[6], [64], [1]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[65]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[67]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[68]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[69]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[70]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[71]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[1]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[5], [6], [72]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[1]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[73], [1]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[74]
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[73], [1]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[75]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[1]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[76]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[77], [78], [79]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[80]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[81], [82]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[83]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[1]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[1]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[73], [1]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [21], [142], [143], [22], [144], [145], [146], [147], [148], [149], [150]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[151]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[1]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[152]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[153]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[5], [6], [154]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[1]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[5], [6], [155]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[156]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[1]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[6], [157], [158], [159]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[157], [158], [159]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[1]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[160]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Moderate		Inter Info	[5], [6], [161]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[5], [6], [155]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[5], [6], [155]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[1]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [21], [142], [143], [22], [144], [145], [146], [147], [148], [149], [150]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [21], [142], [143], [22], [144], [145], [146], [147], [148], [149], [150]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[110], [120], [22]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[110], [120], [22]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[162]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[163]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[5], [6], [164]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[165]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[167]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Moderate		Inter Info	[73], [1]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[168]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[1]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[170], [171], [176]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[6], [184]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[185]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[1]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[186]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[5], [6], [187]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[188]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[110], [120], [22]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[5], [6], [155]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[5], [6], [155]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[189], [190]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[191], [192]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[1]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[193]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[1]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[1]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[194]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[195]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[196], [197], [198], [199]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[196], [197], [198]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[5], [6], [200]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[1]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[6], [201]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[1]
D0683		Fluticasone	C22H27F3O4S	5311101	Moderate		Inter Info	[1]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[202]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[5], [206]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[5], [6], [207]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[208]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[209]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[210]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Moderate		Inter Info	[73], [1]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[1]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[1]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[211], [5], [212], [213]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [21], [142], [143], [22], [144], [145], [146], [147], [148], [149], [150]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[5], [214], [215], [216], [217]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[110], [120], [22]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[218], [219], [14], [220], [221], [222]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[223]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[224], [225], [226]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Moderate		Inter Info	[73], [1]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[227]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[1]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[228]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[73], [1]
D1428		Ropivacaine	C17H26N2O	175805	Moderate		Inter Info	[1]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[229]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[1]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[230]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[73], [1]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[231], [232], [233], [234]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[5], [6], [235]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[5], [6], [236], [237]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[238]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[5], [6], [207]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[5], [6], [207]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[239], [240]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[5], [6], [236], [237]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[6], [241], [242]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[1]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[243]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1], [63]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[5], [6], [244]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[73], [1]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[73], [1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[8], [6], [245], [246], [247]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[1]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[5], [248]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[249], [5], [6], [250], [251]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[1]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[1]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[1]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[1]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[73], [1]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[252]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[1]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[1]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[253]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[1]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[254], [255]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[256]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[257], [258], [259]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[260]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[262], [263], [264]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[34], [265]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[266], [267], [268], [269]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[270]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[271], [272]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 230
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0001		Abacavir	C14H18N6O	441300	Major		Inter Info	[1]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[1]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1]
D0009		Acarbose	C25H43NO18	41774	Major		Inter Info	[1]
D0011		Acetaminophen	C8H9NO2	1983	Major		Inter Info	[1]
D0018		Acitretin	C21H26O3	5284513	Major		Inter Info	[1]
D0026		Afatinib	C24H25ClFN5O3	10184653	Major		Inter Info	[1]
D0030		Aldesleukin	NA	NA	Major		Inter Info	[1]
D0031		Alectinib	C30H34N4O2	49806720	Major		Inter Info	[1]
D0053		Ambrisentan	C22H22N2O4	6918493	Major		Inter Info	[1]
D0065		Aminosalicylic acid	C7H7NO3	4649	Major		Inter Info	[1]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Major		Inter Info	[1]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[1]
D0120		Atorvastatin	C33H35FN2O5	60823	Major		Inter Info	[1]
D0121		Atovaquone	C22H19ClO3	74989	Major		Inter Info	[1]
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[1]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[1]
D0153		Belinostat	C15H14N2O4S	6918638	Major		Inter Info	[1]
D0156		Benazepril	C24H28N2O5	5362124	Major		Inter Info	[1]
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[1]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[1]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Major		Inter Info	[1]
D0191		Blinatumomab	NA	NA	Major		Inter Info	[1]
D0193		Bortezomib	C19H25BN4O4	387447	Major		Inter Info	[1]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[1]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[1]
D0199		Brentuximab vedotin	NA	NA	Major		Inter Info	[1]
D0210		Bromfenac	C15H12BrNO3	60726	Major		Inter Info	[1]
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1]
D0248		Cannabidiol	C21H30O2	644019	Major		Inter Info	[1]
D0254		Captopril	C9H15NO3S	44093	Major		Inter Info	[1]
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[1]
D0264		Carmustine	C5H9Cl2N3O2	2578	Major		Inter Info	[1]
D0268		Caspofungin	C52H88N10O15	2826718	Major		Inter Info	[1]
D0298		Celecoxib	C17H14F3N3O2S	2662	Major		Inter Info	[1]
D0303		Cerivastatin	C26H34FNO5	446156	Major		Inter Info	[1]
D0310		Chenodeoxycholic acid	C24H40O4	10133	Major		Inter Info	[1]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Major		Inter Info	[1]
D0350		Clavulanic acid	C8H9NO5	5280980	Major		Inter Info	[1]
D0357		Clofarabine	C10H11ClFN5O3	119182	Major		Inter Info	[1]
D0367		Clotrimazole	C22H17ClN2	2812	Major		Inter Info	[1]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[1]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[1]
D0407		Dacarbazine	C6H10N6O	135398738	Major		Inter Info	[1]
D0416		Danazol	C22H27NO2	28417	Major		Inter Info	[1]
D0417		Dantrolene	C14H10N4O5	6914273	Major		Inter Info	[1]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[1]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[1]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[1]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Major		Inter Info	[1]
D0483		Didanosine	C10H12N4O3	135398739	Major		Inter Info	[1]
D0499		Dimethyl fumarate	C6H8O4	637568	Major		Inter Info	[1]
D0509		Disulfiram	C10H20N2S4	3117	Major		Inter Info	[1]
D0530		Doxycycline	C22H24N2O8	54671203	Major		Inter Info	[1]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1]
D0539		Duloxetine	C18H19NOS	60835	Major		Inter Info	[1]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1]
D0555		Elagolix	C32H30F5N3O5	11250647	Major		Inter Info	[1]
D0560		Elotuzumab	NA	NA	Major		Inter Info	[1]
D0561		Eltrombopag	C25H22N4O4	135449332	Major		Inter Info	[1]
D0566		Emtricitabine	C8H10FN3O3S	60877	Major		Inter Info	[1]
D0567		Enalapril	C20H28N2O5	5388962	Major		Inter Info	[1]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[1]
D0595		Erlotinib	C22H23N3O4	176870	Major		Inter Info	[1]
D0616		Ethambutol	C10H24N2O2	14052	Major		Inter Info	[1]
D0617		Ethanol	C2H6O	702	Major		Inter Info	[1]
D1731		Ethionamide	C8H10N2S	2761171	Major		Inter Info	[1]
D0621		Ethotoin	C11H12N2O2	3292	Major		Inter Info	[1]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[1]
D0637		Febuxostat	C16H16N2O3S	134018	Major		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[6], [26]
D0639		Felbamate	C11H14N2O4	3331	Major		Inter Info	[1]
D0642		Fenofibrate	C20H21ClO4	3339	Major		Inter Info	[1]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[1]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[1]
D0677		Fluoxymesterone	C20H29FO3	6446	Major		Inter Info	[1]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[1]
D0682		Flutamide	C11H11F3N2O3	3397	Major		Inter Info	[1]
D0686		Fluvastatin	C24H26FNO4	446155	Major		Inter Info	[1]
D0695		Fosinopril	C30H46NO7P	55891	Major		Inter Info	[1]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Major		Inter Info	[1]
D0713		Gefitinib	C22H24ClFN4O3	123631	Major		Inter Info	[1]
D0714		Gemcitabine	C9H11F2N3O4	60750	Major		Inter Info	[1]
D0717		Gemtuzumab ozogamicin	NA	NA	Major		Inter Info	[1]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[1]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[1]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[1]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[1]
D0802		Infliximab	NA	NA	Major		Inter Info	[1]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[1]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Major		Inter Info	[1]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Major		Inter Info	[1]
D0824		Interferon alfa-n1	NA	NA	Major		Inter Info	[1]
D0823		Interferon alfacon-1	NA	NA	Major		Inter Info	[1]
D0826		Interferon beta-1a	NA	NA	Major		Inter Info	[1]
D0827		Interferon beta-1b	NA	NA	Major		Inter Info	[1]
D0828		Interferon gamma-1b	NA	NA	Major		Inter Info	[1]
D0841		Ipilimumab	NA	NA	Major		Inter Info	[1]
D0858		Isoniazid	C6H7N3O	3767	Major		Inter Info	[1]
D0863		Isotretinoin	C20H28O2	5282379	Major		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[1]
D0878		Kava	C14H16O3	5281052	Major		Inter Info	[1]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[1]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1]
D0884		Labetalol	C19H24N2O3	3869	Major		Inter Info	[1]
D0889		Lamivudine	C8H11N3O3S	60825	Major		Inter Info	[1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[1]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[1]
D0902		Lenalidomide	C13H13N3O3	216326	Major		Inter Info	[1]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Major		Inter Info	[1]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[1]
D0938		Lisinopril	C21H31N3O5	5362119	Major		Inter Info	[1]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[1]
D0945		Lomustine	C9H16ClN3O2	3950	Major		Inter Info	[1]
D0956		Lovastatin	C24H36O5	53232	Major		Inter Info	[1]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Major		Inter Info	[1]
D0980		Maraviroc	C29H41F2N5O	3002977	Major		Inter Info	[1]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[1]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[1]
D1003		Mephenytoin	C12H14N2O2	4060	Major		Inter Info	[1]
D1007		Mercaptopurine	C5H4N4S	667490	Major		Inter Info	[1]
D1014		Metaxalone	C12H15NO3	15459	Major		Inter Info	[1]
D1021		Methimazole	C4H6N2S	1349907	Major		Inter Info	[1]
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[1]
D1035		Methyldopa	C10H13NO4	38853	Major		Inter Info	[1]
D1042		Methyltestosterone	C20H30O2	6010	Major		Inter Info	[1]
D1066		Milnacipran	C15H22N2O	65833	Major		Inter Info	[1]
D1070		Minocycline	C23H27N3O7	54675783	Major		Inter Info	[1]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[1]
D1082		Moexipril	C27H34N2O7	91270	Major		Inter Info	[1]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[1]
D1106		Naltrexone	C20H23NO4	5360515	Major		Inter Info	[1]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[1]
D1111		Natalizumab	NA	NA	Major		Inter Info	[1]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[1]
D1129		Niacin	C6H5NO2	938	Major		Inter Info	[1]
D1132		Nicotinamide	C6H6N2O	936	Major		Inter Info	[1]
D1137		Nilutamide	C12H10F3N3O4	4493	Major		Inter Info	[1]
D1139		Nintedanib	C31H33N5O4	135423438	Major		Inter Info	[1]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Major		Inter Info	[1]
D1187		Orlistat	C29H53NO5	3034010	Major		Inter Info	[1]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[1]
D1195		Oxandrolone	C19H30O3	5878	Major		Inter Info	[1]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[1]
D1207		Oxymetholone	C21H32O3	5281034	Major		Inter Info	[1]
D1209		Oxytetracycline	C22H24N2O9	54675779	Major		Inter Info	[1]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[1]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[1]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[1]
D1237		Peginterferon alfa-2a	NA	NA	Major		Inter Info	[1]
D1238		Peginterferon alfa-2b	NA	NA	Major		Inter Info	[1]
D1239		Peginterferon beta-1a	NA	NA	Major		Inter Info	[1]
D1243		Pemoline	C9H8N2O2	4723	Major		Inter Info	[1]
D1256		Perindopril	C19H32N2O5	107807	Major		Inter Info	[1]
D0232		Calaspargase pegol	NA	NA	Major		Inter Info	[1]
D0507		Diroximel fumarate	C11H13NO6	73330464	Major		Inter Info	[1]
D0643		Fenofibric acid	C17H15ClO4	64929	Major		Inter Info	[1]
D0724		Givosiran	C78H139N11O30	119058042	Major		Inter Info	[1]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[1]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Major		Inter Info	[1]
D1085		Monomethyl fumarate	C5H6O4	5369209	Major		Inter Info	[1]
D1180		Onasemnogene abeparvovec	NA	NA	Major		Inter Info	[1]
D1324		Pralsetinib	C27H32FN9O2	129073603	Major		Inter Info	[1]
D1327		Prasterone enantate	C26H40O3	163331	Major		Inter Info	[1]
D1448		Satralizumab	NA	NA	Major		Inter Info	[1]
D1531		Tagraxofusp	NA	NA	Major		Inter Info	[1]
D1261		Phenazopyridine	C11H11N5	4756	Major		Inter Info	[1]
D1274		Phenylbutazone	C19H20N2O2	4781	Major		Inter Info	[1]
D1294		Pioglitazone	C19H20N2O3S	4829	Major		Inter Info	[1]
D1299		Pirfenidone	C12H11NO	40632	Major		Inter Info	[1]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[1]
D1301		Pitavastatin	C25H24FNO4	5282452	Major		Inter Info	[1]
D1306		Polatuzumab vedotin	NA	NA	Major		Inter Info	[1]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[1]
D1323		Pralatrexate	C23H23N7O5	148121	Major		Inter Info	[1]
D1329		Pravastatin	C23H36O7	54687	Major		Inter Info	[1]
D1359		Propylthiouracil	C7H10N2OS	657298	Major		Inter Info	[1]
D1364		Pyrazinamide	C5H5N3O	1046	Major		Inter Info	[1]
D1369		Quinapril	C25H30N2O5	54892	Major		Inter Info	[1]
D1379		Ramipril	C23H32N2O5	5362129	Major		Inter Info	[1]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[1]
D1405		Riluzole	C8H5F3N2OS	5070	Major		Inter Info	[1]
D1421		Rofecoxib	C17H14O4S	5090	Major		Inter Info	[1]
D1429		Rosiglitazone	C18H19N3O3S	77999	Major		Inter Info	[1]
D1447		Sarilumab	NA	NA	Major		Inter Info	[1]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[1]
D1503		Stanozolol	C21H32N2O	25249	Major		Inter Info	[1]
D1504		Stavudine	C10H12N2O4	18283	Major		Inter Info	[1]
D1513		Sulfadiazine	C10H10N4O2S	5215	Major		Inter Info	[1]
D1514		Sulfadoxine	C12H14N4O4S	17134	Major		Inter Info	[1]
D1515		Sulfamethizole	C9H10N4O2S2	5328	Major		Inter Info	[1]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Major		Inter Info	[1]
D1517		Sulfasalazine	C18H14N4O5S	5339	Major		Inter Info	[1]
D1519		Sulfisoxazole	C11H13N3O3S	5344	Major		Inter Info	[1]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[1]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[1]
D1525		Tacrine	C13H14N2	1935	Major		Inter Info	[1]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[1]
D1548		Temozolomide	C6H6N6O2	5394	Major		Inter Info	[1]
D1553		Terbinafine	C21H25N	1549008	Major		Inter Info	[1]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[1]
D1558		Testosterone	C19H28O2	6013	Major		Inter Info	[1]
D1559		Testosterone (topical)	C19H28O2	6013	Major		Inter Info	[1]
D1564		Tetracycline	C22H24N2O8	54675776	Major		Inter Info	[1]
D1589		Tioguanine	C5H5N5S	2723601	Major		Inter Info	[1]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[1]
D1599		Tocilizumab	NA	NA	Major		Inter Info	[1]
D1604		Tolcapone	C14H11NO5	4659569	Major		Inter Info	[1]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[1]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[1]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[1]
D1618		Trandolapril	C24H34N2O5	5484727	Major		Inter Info	[1]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[1]
D1626		Tretinoin	C20H28O2	444795	Major		Inter Info	[1]
D1646		Trimetrexate	C19H23N5O3	5583	Major		Inter Info	[1]
D1652		Troglitazone	C24H27NO5S	5591	Major		Inter Info	[1]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Major		Inter Info	[1]
D1674		Valdecoxib	C16H14N2O3S	119607	Major		Inter Info	[1]
D1677		Valproic acid	C8H16O2	3121	Major		Inter Info	[1]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[1]
D1698		Vincristine	C46H56N4O10	5978	Major		Inter Info	[1]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Major		Inter Info	[1]
D1714		Zafirlukast	C31H33N3O6S	5717	Major		Inter Info	[1]
D1715		Zalcitabine	C9H13N3O3	24066	Major		Inter Info	[1]
D1720		Zidovudine	C10H13N5O4	35370	Major		Inter Info	[1]
D1721		Zileuton	C11H12N2O2S	60490	Major		Inter Info	[1]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[5], [6], [203], [204], [205]

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238	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
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259	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
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261	Product Information. Dificid (fidaxomicin). Optimer Pharmaceuticals, San Diego, CA.
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