Details of Drug-Drug Interaction
| Drug General Information (ID: DDI4GA5ZOF) | |||||||||
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| Drug Name | Epoprostenol | Drug Info | Licorice | Drug Info | |||||
| Drug Type | Small molecule | Natural product | |||||||
| Therapeutic Class | Antihypertensive Agents | Herbal Products | |||||||
| Structure | |||||||||
| Mechanism of Epoprostenol-Licorice Interaction (Severity Level: Moderate) | |||||||||
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| Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Epoprostenol | Licorice | |||||||
| Mechanism |
Antihypertensive agent Prostacyclin receptor Agonist |
Hypertensive effects Mineralocorticoid and renin-suppressing effects |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Prostacyclin receptor |
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Structure
Sequence
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
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| Gene Name | PTGIR | ||||||||
| Uniprot ID | PI2R_HUMAN | ||||||||
| KEGG Pathway | hsa:5739 | ||||||||
| Protein Family | G-protein coupled receptor 1 family | ||||||||
| Protein Function |
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
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| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Patients receiving antihypertensive therapy should avoid or limit the consumption of licorice-containing products. Even relatively moderate doses of licorice may be problematic in susceptible patients when ingested regularly for prolonged periods. | ||||||||