Drug General Information (ID: DDI48LD57U)
Drug Name			Dipyridamole		Drug Info		Fludarabine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasodilator Agents				Antineoplastics
Structure

Mechanism of Dipyridamole-Fludarabine Interaction (Severity Level: Moderate)
Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph
Drug Name		Dipyridamole				Fludarabine
Mechanism		Inhibit the cellular uptake of adenine analogs				Adenine analogs
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Interference of cell/tissue uptake of Fludarabine by Dipyridamole

Recommended Action
Management		Although clinical data are lacking, it may be advisable to avoid this combination.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Multum Information Services, Inc. Expert Review Panel.