Details of Drug

Drug General Information (ID: D0506)
Drug Name	Dipyridamole
Drug Type	Small molecule
Drug Synonymous	Agilease; Anginal; Antistenocardin; Apricor; Cardioflux; Cardoxil; Cardoxin; Cerebrovase; Chilcolan; Cleridium; Coribon; Coridil; Coronarine; Corosan; Coroxin; Curantil; Curantyl; Dipiridamol; Dipyramidole; Dipyridamine; Dipyridamol; Dipyridamolum; Dipyridan; Dipyudamine; Dypyridamol; Gulliostin; Justpertin; Kurantil; Miosen; Natyl; Peridamol; Permiltin; Persantin; Persantine; Piroan; Prandiol; Protangix; Stenocardil; Stenocardiol; Stimolcardio; Apotex Brand of Dipyridamole; Ashbourne Brand of Dipyridamole; Belmac Brand of Dipyridamole; Berlin Chemie Brand of Dipyridamole; Boehringer Ingelheim Brand of Dipyridamole; IPRAD Brand of Dipyridamole; Iv Persantine; Novopharm Brand of Dipyridamole; Cleridium 150; D 9766; Prandiol 75; Apo-Dipyridamole; Apo-Dipyridamole Fc; Apo-Dipyridamole Sc; Berlin-Chemie Brand of Dipyridamole; Dipiridamol [INN-Spanish]; Dipyridamolum [INN-Latin]; Novo-Dipiradol; Persantine (TN); RA-8; Usaf Ge-12; Dipyridamole (JP15/USP/INN); Dipyridamole [USAN:INN:BAN:JAN]; Permole, Persantine, Dipyridan, Dipyridamole; 2,6-Bis(diethanolamine)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine; 2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido(5,4-d)pyrimidine; 2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine Click to Show/Hide
Disease Class	BA00-BA04: Hypertension
Therapeutic Class	Vasodilator Agents
Structure
Structure	3D Structure		2D Structure
Formula	C24H40N8O4
InChI	1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
InChIKey	IZEKFCXSFNUWAM-UHFFFAOYSA-N
Canonical SMILES	C1CCN(CC1)C2=NC(=NC3=C2N=C(N=C3N4CCCCC4)N(CCO)CCO)N(CCO)CCO
External Link
	Pubchem ID	3108
	CAS Number	58-32-2
	CHEBI ID	4653
	TTD ID	D0F9GE
	INTEDE ID	DR2282
	VARIDT ID	DR00613

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM003 Affected organization distribution AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM014 Interference of cell/tissue uptake BM042 Additive hypotensive effects BM050 Increased risk of bleeding BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Dipyridamole
Affected cellular transport
	Transporter inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Moderate		Inter Info	[22], [16], [115]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[16], [129]
D1906		Thallous Chloride	ClTl	24642	Moderate		Inter Info	[22], [172], [173]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1408		Riociguat	C20H19FN8O2	11304743	Major		Inter Info	[22], [16], [42]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[164]
	Increased risk of bleeding					Drug Num: 125
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1], [2], [3], [4]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[12], [13], [14]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[15]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[16], [17]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[16], [18]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[19]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[20]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[16], [21]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[22], [16], [23]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0415		Danaparoid	NA	NA	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[24]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[25], [26]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[16], [27]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[28], [29]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[30]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[31], [32], [16], [33]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[16], [25], [34]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[25], [35]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[22], [16], [36]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[37]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[16], [38]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[39]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[16], [40], [41]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[43]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[22], [16], [44]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[45]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[25]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[46]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1], [2], [3], [4]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[47]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[12], [13], [14]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[48]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1], [2], [3], [4]
D1613		Tositumomab	NA	NA	Major		Inter Info	[49], [50]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[49], [50]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58]
D0088		Anistreplase	NA	NA	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[59], [22], [16], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[13]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[70], [71], [72]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[70], [71], [72]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[76]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0384		Collagenase clostridium histolyticum	NA	NA	Moderate		Inter Info	[116]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[70], [71], [72]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[70], [71], [72]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[70], [71], [72]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[117], [73], [118]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[70], [71], [72]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[119], [120], [117], [73], [118], [121]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[59], [22], [16], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[59], [22], [16], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[122], [123], [124]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[25], [125]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[126], [127], [128]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0711		Garlic	NA	NA	Moderate		Inter Info	[130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[135], [145], [146], [139], [142]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[147], [148], [149], [150], [132], [151], [152], [133], [135], [136], [153], [145], [154], [139], [155], [156], [157], [142], [158]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[159], [133], [135], [160], [136], [161], [139], [142], [162]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[163]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[70], [71], [72]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[126], [127], [128]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[70], [71], [72]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[70], [71], [72]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[165]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[16], [166]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[16], [167], [168]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[70], [71], [72]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[169], [170], [171]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[16], [174]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[70], [71], [72]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[70], [71], [72]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[70], [71], [72]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[70], [71], [72]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[16], [167], [168]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[70], [71], [72]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[70], [71], [72]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[70], [71], [72]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[70], [71], [72]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[70], [71], [72]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[70], [71], [72]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[70], [71], [72]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[70], [71], [72]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[59], [22], [16], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[25], [175]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[176], [177]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[70], [71], [72]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[70], [71], [72]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[76]
D1506		Streptokinase	C11H19NO2	9815560	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[70], [71], [72]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[70], [71], [72]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[70], [71], [72]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[126], [127], [128]
D1669		Urokinase	NA	NA	Moderate		Inter Info	[51], [52], [53], [54], [55], [56], [57], [58]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[76]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[77], [78], [79], [80], [22], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[169], [180], [16], [181], [182], [183], [184], [135], [185], [186], [187], [188], [189], [190], [191], [170], [192], [193], [171], [194]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[119], [120], [117], [73], [118], [121]
D0253		Capsicum	NA	NA	Minor		Inter Info	[135]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[135], [195], [139]
D0368		Clove	NA	NA	Minor		Inter Info	[135], [196], [197], [198]
D0753		Heparin	C26H42N2O37S5	772	Minor		Inter Info	[199]
D1661		Turmeric	C21H20O6	969516	Minor		Inter Info	[200], [135], [201]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0231		Caffeine	C8H10N4O2	2519	Moderate		Inter Info	[73], [74], [75]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[73], [74], [75]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[73], [74], [75]
D0544		Dyphylline	C10H14N4O4	3182	Moderate		Inter Info	[73], [74], [75]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[73], [74], [75]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[178], [179]

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