Drug General Information (ID: DDI483M7VY)
Drug Name			Ethanol		Drug Info		Promethazine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Antiallergic Agents
Structure

Mechanism of Ethanol-Promethazine Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Ethanol				Promethazine
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Ethanol and Promethazine

Recommended Action
Management		Patients should be advised to avoid alcohol during phenothiazine therapy.

References
1	Freed E "Alcohol-triggered-neuroleptic-induced tremor, rigidity and dystonia." Med J Aust 2 (1981): 44-5
2	Lutz EG "Neuroleptic-induced akathisia and dystonia triggered by alcohol." JAMA 236 (1976): 2422-3