Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDI3Z5T0F2)
  Drug Name Pralidoxime Drug Info Mivacurium Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antidotes Neuromuscular Blocking Agents
  Structure

 Mechanism of Pralidoxime-Mivacurium Interaction (Severity Level: Moderate)
     Antagonize the effect of neuromuscular blocking agents Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Pralidoxime Mivacurium
      Mechanism Anti-neuromuscular blocking effect
Acetylcholinesterase  Activator 		Neuromuscular blocking agent
Acetylcholinesterase  Substrate
      Key Mechanism Factor 1
Factor Name Acetylcholinesterase
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Structure Sequence
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
Gene Name ACHE
Uniprot ID ACES_HUMAN
KEGG Pathway hsa:43
Protein Family Type-B carboxylesterase/lipase family
Protein Function
Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis.
    Click to Show/Hide
      Mechanism Description
  • Antagonize the effect of Mivacurium when combined with Pralidoxime 

Recommended Action
      Management Neuromuscular effects should be monitored when succinylcholine or mivacurium is coadministered with an oxime.

References
1 Product Information. DuoDote (atropine-pralidoxime). Meridian Medical Technologies Inc, Columbia, MD.
2 Selden BS, Curry SC "Prolonged succinylcholine-induced paralysis in organophosphate insecticide poisoning." Ann Emerg Med 16 (1987): 215-7. [PMID: 2432808]