Drug General Information (ID: DDI3EGZPU1)
Drug Name			Pancrelipase		Drug Info		Acarbose		Drug Info
Drug Type		Protein/peptide				Small molecule
Therapeutic Class		Digestive Enzymes				Antidiabetic Agents
Structure

Mechanism of Pancrelipase-Acarbose Interaction (Severity Level: Moderate)
Antagonize the effect of alpha-glucosidase inhibitors Click to Show/Hide Mechanism Graph
Drug Name		Pancrelipase				Acarbose
Mechanism		Pancreatic enzymes				Alpha-glucosidase inhibitor
Key Mechanism Factor 1
		Factor Name		Alpha-glucosidase inhibitors
		Factor Description		The hypoglycemic effect of alpha-glucosidase inhibitors may be reduced, leading to increased blood glucose.
Mechanism Description		Antagonize the effect of Acarbose when combined with Pancrelipase

Recommended Action
Management		Alpha-glucosidase inhibitors should not be administered simultaneously with intestinal adsorbents or preparations containing carbohydrate-splitting digestive enzymes. The optimal dosing interval between these agents has not been established. Postprandial blood glucose and glycosylated hemoglobin (HbA1c) should be monitored to ensure adequate therapeutic response to alpha-glucosidase inhibitor therapy.

References
1	Product Information. Glyset (miglitol). Bayer, West Haven, CT.
2	Product Information. Precose (acarbose). Bayer, West Haven, CT.