Drug General Information (ID: DDI35D2LC4)
Drug Name			Etelcalcetide		Drug Info		Burosumab		Drug Info
Drug Type		Small molecule				Monoclonal antibody
Therapeutic Class		Calcimimetics				Metabolic Agents

Mechanism of Etelcalcetide-Burosumab Interaction (Severity Level: Moderate)
Increased risk of hypocalcemia Click to Show/Hide Mechanism Graph
Drug Name		Etelcalcetide				Burosumab
Mechanism		Hypocalcemia				Hypocalcemia
Key Mechanism Factor 1
		Factor Name		Hypocalcemia
		Factor Description		Hypocalcemia is a low level of calcium found in a blood test. It can cause symptoms such as tingling, muscle cramps and heart rhythm problems that can range from mild to life-threatening.
Mechanism Description		Increased risk of hypocalcemia by the combination of Etelcalcetide and Burosumab

Recommended Action
Management		Until further information is available, caution is advised when combining burosumab with calcimimetic drugs.

References
1	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".