Drug General Information (ID: DDI35AIDOH)
Drug Name			Pilocarpine		Drug Info		Carvedilol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cholinergic Agents				Vasodilator Agents
Structure

Mechanism of Pilocarpine-Carvedilol Interaction (Severity Level: Moderate)
Increased risk of atrioventricular block Click to Show/Hide Mechanism Graph
Drug Name		Pilocarpine				Carvedilol
Mechanism		Delay atrioventricular conduction				Delay atrioventricular conduction
Key Mechanism Factor 1
		Factor Name		Atrioventricular block
		Factor Description		Atrioventricular block is a type of cardiac conduction block that occurs when the electrical signal from the atria to the ventricles is impaired. In an Atrioventricular block, this electrical signal is either delayed or completely blocked. When the signal is completely blocked, the ventricles produce their own electrical signal to control the heart rate. The heart rate produced by the ventricles is much slower than that produced by the sinus node.
Mechanism Description		Increased risk of atrioventricular block by the combination of Pilocarpine and Carvedilol

Recommended Action
Management		If these drugs must be given together, consider the possibility for arrhythmias and administer with caution. Patients should be advised to notify their physician if they experience irregular or slow heartbeats, palpitations, or syncope.

References
1	Product Information. Salagen Tablets (pilocarpine). Boehringer-Ingelheim, Ridgefield, CT.