Details of Drug

Details of Drug

 Drug General Information (ID: D1288)
  Drug Name
Pilocarpine
  Drug Type Small molecule
  Drug Synonymous
Adsorbocarpine; Almocarpine; Epicar; Isopilocarpine; Isoptocarpine; Miocarpine; Ocusert; Pilagan; Pilocarpin; Pilocarpol; Pilokarpin; Pilokarpol; Pilostat; Salagen; Spersacarpine; Syncarpine; Amistura P; Isopto carpine; Minims Pilocarpine; Ocusert pilo; Pilocarpine HCl; Pilocarpine chloride; Pilocarpine nitrate; Ocusert P 20;Beta-Pilocarpine hydrochloride; Diocarpine (TN); Isopto Carpine (TN); Mi-Pilo; Miocarpine (TN); Ocu-Carpine; Ocusert Pilo-40; Ocusert pilo-20; Pilocarpine (TN); Pilopine HS (TN); Piloptic-1; Piloptic-2; Piloptic-3; Piloptic-4; Piloptic-6; Salagen (TN); Scheinpharm (TN); Timpilo (TN); Ocusert Pilo-20 (TN); Ocusert pilo-20 (TN); P.V. Carpine Liquifilm; Pilocarpine (JAN/USP); Pilocarpine [USAN:BAN:JAN]; Piloptic-1/2; Pilocarpine Mononitrate, (3S-cis)-Isomer; Pilocarpine, Monohydrochloride, (3S-cis)-Isomer; Imidazole-5-butyric acid, alpha-ethyl-beta-(hydroxymethyl)-1-methyl-, gamma-lactone; (+)-Pilocarpine; (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one; (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one; (3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone; (3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone; (3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone; 3-Ethyl-4-(3-methyl-3H-imidazol-4-ylmethyl)dihydrofuran-2-one; 3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydro-2(3H)-furanone; 3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one; 3-ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydro-2(3H)-furanone; 3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
    Click to Show/Hide
  Disease Class 9C61: Glaucoma
  Therapeutic Class Cholinergic Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C11H16N2O2
  InChI 1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1
  InChIKey QCHFTSOMWOSFHM-WPRPVWTQSA-N
  Canonical SMILES CCC1C(COC1=O)CC2=CN=CN2C
  External Link
Pubchem ID 5910
CAS Number 92-13-7
CHEBI ID 8207
TTD ID D06HLY
INTEDE ID DR1285
VARIDT ID DR00888

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM037  Additive cholinergic effects
BM049  Increased risk of atrioventricular block
BM051  Increased risk of bradycardia
BM081  Increased risk of ventricular arrhythmias
BM091  Antagonize the effect of cholinergic agents
  Relation Graph
 Full list of drugs interacting with Pilocarpine
      Pharmacodynamic additive effects
   Additive cholinergic effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0054
 
Amifampridine
 
C5H7N3
 
5918 
Moderate    Inter Info   
[7], [8]
   Increased risk of atrioventricular block Drug Num:  22
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0117
 
Atenolol
 
C14H22N2O3
 
2249 
Moderate    Inter Info   
[3]
D0173
 
Betaxolol
 
C18H29NO3
 
2369 
Moderate    Inter Info   
[3]
D0174
 
Betaxolol (ophthalmic)
 
C18H29NO3
 
2369 
Moderate    Inter Info   
[3]
D0188
 
Bisoprolol
 
C18H31NO4
 
2405 
Moderate    Inter Info   
[3]
D0265
 
Carteolol
 
C16H24N2O3
 
2583 
Moderate    Inter Info   
[3]
D0266
 
Carteolol (ophthalmic)
 
C16H24N2O3
 
2583 
Moderate    Inter Info   
[3]
D0602
 
Esmolol
 
C16H25NO4
 
59768 
Moderate    Inter Info   
[3]
D0884
 
Labetalol
 
C19H24N2O3
 
3869 
Moderate    Inter Info   
[3]
D1049
 
Metoprolol
 
C15H25NO3
 
4171 
Moderate    Inter Info   
[3]
D0010
 
Acebutolol
 
C18H28N2O4
 
1978 
Moderate    Inter Info   
[3]
D0267
 
Carvedilol
 
C24H26N2O4
 
2585 
Moderate    Inter Info   
[3]
D0914
 
Levobetaxolol (ophthalmic)
 
C18H29NO3
 
60657 
Moderate    Inter Info   
[3]
D0915
 
Levobunolol (ophthalmic)
 
C17H25NO3
 
39468 
Moderate    Inter Info   
[3]
D1045
 
Metipranolol (ophthalmic)
 
C17H27NO4
 
31477 
Moderate    Inter Info   
[3]
D1098
 
Nadolol
 
C17H27NO4
 
39147 
Moderate    Inter Info   
[3]
D1114
 
Nebivolol
 
C22H25F2NO4
 
71301 
Moderate    Inter Info   
[3]
D1244
 
Penbutolol
 
C18H29NO2
 
37464 
Moderate    Inter Info   
[3]
D1293
 
Pindolol
 
C14H20N2O2
 
4828 
Moderate    Inter Info   
[3]
D1357
 
Propranolol
 
C16H21NO2
 
4946 
Moderate    Inter Info   
[3]
D1498
 
Sotalol
 
C12H20N2O3S
 
5253 
Moderate    Inter Info   
[3]
D1585
 
Timolol
 
C13H24N4O3S
 
33624 
Moderate    Inter Info   
[3]
D1586
 
Timolol (ophthalmic)
 
C13H24N4O3S
 
33624 
Moderate    Inter Info   
[3]
   Increased risk of bradycardia Drug Num:  8
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1474
 
Siponimod
 
C29H35F3N2O3
 
44599207 
Major    Inter Info   
[1], [2]
D0031
 
Alectinib
 
C30H34N4O2
 
49806720 
Moderate    Inter Info   
[5], [6]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[9]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Moderate    Inter Info   
[10], [11], [12]
D0661
 
Fingolimod
 
C19H33NO2
 
107970 
Moderate    Inter Info   
[13], [14]
D0868
 
Ivabradine
 
C27H36N2O5
 
132999 
Moderate    Inter Info   
[1], [15]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Moderate    Inter Info   
[16]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Moderate    Inter Info   
[17]
   Increased risk of ventricular arrhythmias Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1569
 
Thalidomide
 
C13H10N2O4
 
5426 
Moderate    Inter Info   
[1], [10], [18]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of cholinergic agents Drug Num:  37
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0123
 
Atropine
 
C17H23NO3
 
174174 
Moderate    Inter Info   
[4], [3]
D0124
 
Atropine (ophthalmic)
 
C17H23NO3
 
174174 
Moderate    Inter Info   
[4], [3]
D0160
 
Benzatropine
 
C21H25NO
 
1201549 
Moderate    Inter Info   
[4], [3]
D0183
 
Biperiden
 
C21H29NO
 
2381 
Moderate    Inter Info   
[4], [3]
D0353
 
Clidinium
 
C22H26NO3+
 
2784 
Moderate    Inter Info   
[4], [3]
D0370
 
Clozapine
 
C18H19ClN4
 
135398737 
Moderate    Inter Info   
[4], [3]
D0399
 
Cyclopentolate (ophthalmic)
 
C17H25NO3
 
2905 
Moderate    Inter Info   
[4], [3]
D0424
 
Darifenacin
 
C28H30N2O2
 
444031 
Moderate    Inter Info   
[4], [3]
D0482
 
Dicyclomine
 
C19H35NO2
 
3042 
Moderate    Inter Info   
[4], [3]
D0498
 
Dimenhydrinate
 
C24H28ClN5O3
 
10660 
Moderate    Inter Info   
[4], [3]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Moderate    Inter Info   
[4], [3]
D0733
 
Glycopyrronium
 
C19H28NO3+
 
3494 
Moderate    Inter Info   
[4], [3]
D0734
 
Glycopyrronium (topical)
 
C19H28NO3+
 
3494 
Moderate    Inter Info   
[4], [3]
D0782
 
Hyoscyamine
 
C17H23NO3
 
154417 
Moderate    Inter Info   
[4], [3]
D0842
 
Ipratropium
 
C20H30NO3+
 
657309 
Moderate    Inter Info   
[4], [3]
D0987
 
Meclizine
 
C25H27ClN2
 
4034 
Moderate    Inter Info   
[4], [3]
D1202
 
Oxybutynin
 
C22H31NO3
 
4634 
Moderate    Inter Info   
[4], [3]
D0019
 
Aclidinium
 
C26H30NO4S2+
 
11434515 
Moderate    Inter Info   
[4], [3]
D0154
 
Belladonna
 
C34H42N2O4
 
265028 
Moderate    Inter Info   
[4], [3]
D0397
 
Cyclizine
 
C18H22N2
 
6726 
Moderate    Inter Info   
[4], [3]
D0662
 
Flavoxate
 
C24H25NO4
 
3354 
Moderate    Inter Info   
[4], [3]
D0760
 
Homatropine (ophthalmic)
 
C16H21NO3
 
5282593 
Moderate    Inter Info   
[4], [3]
D1000
 
Mepenzolate
 
C21H26NO3+
 
4057 
Moderate    Inter Info   
[4], [3]
D1031
 
Methscopolamine
 
C18H24NO4+
 
71183 
Moderate    Inter Info   
[4], [3]
D1396
 
Revefenacin
 
C35H43N5O4
 
11753673 
Moderate    Inter Info   
[4], [3]
D1491
 
Solifenacin
 
C23H26N2O2
 
154059 
Moderate    Inter Info   
[4], [3]
D1590
 
Tiotropium
 
C19H22NO4S2+
 
5487427 
Moderate    Inter Info   
[4], [3]
D1665
 
Umeclidinium
 
C29H34NO2+
 
11519070 
Moderate    Inter Info   
[4], [3]
D1343
 
Procainamide
 
C13H21N3O
 
4913 
Moderate    Inter Info   
[4], [3]
D1347
 
Procyclidine
 
C19H29NO
 
4919 
Moderate    Inter Info   
[4], [3]
D1354
 
Propantheline
 
C23H30NO3+
 
4934 
Moderate    Inter Info   
[4], [3]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Moderate    Inter Info   
[4], [3]
D1450
 
Scopolamine
 
C17H21NO4
 
3000322 
Moderate    Inter Info   
[4], [3]
D1451
 
Scopolamine (ophthalmic)
 
C17H21NO4
 
3000322 
Moderate    Inter Info   
[4], [3]
D1607
 
Tolterodine
 
C22H31NO
 
443879 
Moderate    Inter Info   
[4], [3]
D1655
 
Tropicamide (ophthalmic)
 
C17H20N2O2
 
5593 
Moderate    Inter Info   
[4], [3]
D1656
 
Trospium
 
C25H30NO3+
 
5284632 
Moderate    Inter Info   
[4], [3]
References
1 Cerner Multum, Inc. "Australian Product Information.".
2 Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
3 Product Information. Salagen Tablets (pilocarpine). Boehringer-Ingelheim, Ridgefield, CT.
4 Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255. [PMID: 376469]
5 Product Information. Kaletra (lopinavir-ritonavir) Abbott Pharmaceutical, Abbott Park, IL.
6 Product Information. Alecensa (alectinib). Genentech, South San Francisco, CA.
7 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
8 Product Information. Firdapse (amifampridine). Catalyst Pharmaceuticals, Inc., Coral Gables, FL.
9 Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
10 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
11 Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
12 Canadian Pharmacists Association "e-CPS."
13 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
14 FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
15 Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
16 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
17 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
18 Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.