Drug General Information (ID: DDI2SH4AWP)
Drug Name			Guanethidine		Drug Info		Licorice		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Antihypertensive Agents				Herbal Products
Structure

Mechanism of Guanethidine-Licorice Interaction (Severity Level: Moderate)
Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Drug Name		Guanethidine				Licorice
Mechanism		Antihypertensive agent Adrenergic neuron  Blocker				Hypertensive effects Mineralocorticoid and renin-suppressing effects
Key Mechanism Factor 1
		Factor Name		Antihypertensive agents
		Factor Description		The hypotensive effect of antihypertensive agents may be reduced, leading to higher blood pressure, increased blood pressure fluctuations, and possible cardiovascular damage.
Mechanism Description		Antagonize the effect of Guanethidine when combined with Licorice

Recommended Action
Management		Patients receiving antihypertensive therapy should avoid or limit the consumption of licorice-containing products. Even relatively moderate doses of licorice may be problematic in susceptible patients when ingested regularly for prolonged periods.

References
1	Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CH, Edwards CR "Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age." Lancet 2 (1987): 821-4. [PMID: 2889032]
2	Cumming AM "Metabolic effects of licorice." Br Med J 1 (1977): 906
3	Epstein MT, Espiner EA, Donald RA, Hughes H "Effect of eating liquorice on the renin-angiotensin aldosterone axis in normal subjects." Br Med J 1 (1977): 488-90