Details of Drug-Drug Interaction
| Drug General Information (ID: DDI2ABUYNE) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Nisoldipine | Drug Info | Lanreotide | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antihypertensive Agents | Somatostatin/Somatostatin Analogs | |||||||
| Structure | |||||||||
| Mechanism of Nisoldipine-Lanreotide Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of bradycardia Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Nisoldipine | Lanreotide | |||||||
| Mechanism | Bradycardia | Bradycardia | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Bradycardia | ||||||||
| Factor Description | Bradycardia is a slow heart rate in which the heart beats less than 60 times per minute. If the heart rate is very slow and the heart is not pumping enough oxygen-rich blood to the body, and you may feel dizzy, very tired or weak, and short of breath. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Caution is advised if somatostatin analogs are prescribed with agents that exhibit bradycardic effects, including ophthalmic formulations of beta-blockers. Heart rate and blood pressure should be monitored. | ||||||||
| References | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Product Information. Sandostatin (octreotide). Sandoz Pharmaceuticals Corporation, East Hanover, NJ. | ||||||||||||||||||
| 2 | Product Information. Somatuline Depot (lanreotide). Ipsen Inc, Milford, MA. | ||||||||||||||||||