Details of Drug

Drug General Information (ID: D0891)
Drug Name	Lanreotide
Drug Type	Small molecule
Drug Synonymous	Lanreotide; Angiopeptin acetate; Somatuline; Somatulin; 127984-74-1; DC 13-116; Autogel; 108736-35-2; BIM 23014; Bim-23014; Lanreotide [INN:BAN]; Lanreotidum [INN-Latin]; Lanreotida [INN-Spanish]; Nal-cyclo(cys-tyr-trp-lys-val-cys)-thr-NH2; 10-(4-Aminobutyl)-19-[(2-amino-3-naphthalen-2-yl-propanoyl)amino]-N-(1 -carbamoyl-2-hydroxy-propyl)-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol -3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14, 17-pentazacycloicosane-4-carboxamide; Somatuline lp (TN); Lanreotide Autogel Click to Show/Hide
Disease Class	5A60-5A61: Pituitary gland disorder
Therapeutic Class	Somatostatin/Somatostatin Analogs
Structure
Structure	3D Structure		2D Structure
Formula	C54H69N11O10S2
InChI	1S/C54H69N11O10S2/c1-29(2)45-54(75)63-44(53(74)65-46(30(3)66)47(57)68)28-77-76-27-43(62-48(69)38(56)23-32-15-18-33-10-4-5-11-34(33)22-32)52(73)60-41(24-31-16-19-36(67)20-17-31)50(71)61-42(25-35-26-58-39-13-7-6-12-37(35)39)51(72)59-40(49(70)64-45)14-8-9-21-55/h4-7,10-13,15-20,22,26,29-30,38,40-46,58,66-67H,8-9,14,21,23-25,27-28,55-56H2,1-3H3,(H2,57,68)(H,59,72)(H,60,73)(H,61,71)(H,62,69)(H,63,75)(H,64,70)(H,65,74)
InChIKey	PUDHBTGHUJUUFI-UHFFFAOYSA-N
Canonical SMILES	CC(C)C1C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC6=CC=CC=C6C=C5)N)C(=O)NC(C(C)O)C(=O)N
External Link
	Pubchem ID	71349
	CAS Number	108736-35-2
	TTD ID	D0M2YE

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM051 Increased risk of bradycardia BM064 Increased risk of hypoglycemia BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents
Relation Graph

Full list of drugs interacting with Lanreotide
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[10], [11], [9], [5]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0391		Copper oxodotreotide Cu-64	NA	NA	Major		Inter Info	[1]
D1778		Dotatate	C65H90N14O19S2	11170867	Moderate		Inter Info	[49]
D1819		Indium In-111 pentetreotide	C62H80InN12O19S2-	131704321	Moderate		Inter Info	[4], [5], [54]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[61]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[2]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[3]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[7], [8], [4], [9], [5]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[37]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[19], [21], [32]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[38]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[39], [40]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[41], [42], [43], [44], [45]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[46], [40]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[47], [48]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[50]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[51]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[47], [52]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[53], [40]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[55], [47], [56]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[57]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[58]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[55], [47], [59], [40]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[60]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[47], [62]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[63]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[55], [47], [64]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[55], [65]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[47], [66]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[67]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[19], [21], [32]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[19], [21], [32]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[68], [69]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[55], [47], [70]
D0425		Darolutamide	C19H19ClN6O2	67171867	Minor		Inter Info	[71]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[72]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[47], [73]
Pharmacodynamic additive effects
	Increased risk of bradycardia					Drug Num: 44
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[4], [5]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[4], [5]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[4], [5]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[4], [5]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[4], [5]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[4], [5]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[4], [5]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[4], [5]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[4], [5]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[4], [5]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[4], [5]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[4], [5]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[4], [5]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[4], [5]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[4], [5]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[4], [5]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[4], [5]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[4], [5]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[4], [5]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[4], [5]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[4], [5]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[4], [5]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[4], [5]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[4], [5]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[4], [5]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[4], [5]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[4], [5]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[4], [5]
D1088		Moricizine	C22H25N3O4S	34633	Moderate		Inter Info	[4], [5]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[4], [5]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[4], [5]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[4], [5]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[4], [5]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[4], [5]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[4], [5]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[4], [5]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[4], [5]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[4], [5]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[4], [5]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[4], [5]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[4], [5]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[4], [5]
D1598		Tocainide	C11H16N2O	38945	Moderate		Inter Info	[4], [5]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[4], [5]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[4], [5], [6]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[4], [5], [6]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[4], [5], [6]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[4], [5], [6]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[4], [5], [6]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[4], [5], [6]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[4], [5], [6]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[4], [5], [6]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[4], [5], [6]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[4], [5], [6]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[4], [5], [6]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[4], [5], [6]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[4], [5], [6]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[4], [5], [6]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[4], [5], [6]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[4], [5], [6]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[4], [5], [6]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[4], [5], [6]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[4], [5], [6]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[4], [5], [6]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[4], [5], [6]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[4], [5], [6]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[4], [5], [6]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[4], [5], [6]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[4], [5], [6]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[4], [5], [6]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[4], [5], [6]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[4], [5], [6]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[4], [5], [6]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[4], [5], [6]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[4], [5], [6]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[4], [5], [6]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[4], [5], [6]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[4], [5], [6]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[4], [5], [6]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[4], [5], [6]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[4], [5], [6]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[4], [5], [6]
	Antagonize the effect of antihypertensive agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[4], [5], [6]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[4], [5], [6]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[4], [5], [6]

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38	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
39	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
40	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
41	Labroo RB, Paine MF, Thummel KE, Kharasch ED "Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implicaitons for interindividual variability in disposition, efficacy, and drug interactions." Drug Metab Dispos 25 (1997): 1072-80. [PMID: 9311623]
42	Product Information. Actiq (fentanyl). Abbott Pharmaceutical, Abbott Park, IL.
43	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
44	Tateishi T, Krivoruk Y, Ueng YF, Wood AJ, Guengerich FP, Wood M "Identification of human cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation." Anesth Analg 82 (1996): 167-72. [PMID: 8712396]
45	Ibrahim AE, Feldman J, Karim A, Kharasch ED "Simultaneous Assessment of Drug Interactions with Low- and High-Extraction Opioids: Application to Parecoxib Effects on the Pharmacokinetics and Pharmacodynamics of Fentanyl and Alfentanil." Anesthesiology 98 (2003): 853-861. [PMID: 12657846]
46	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
47	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
48	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
49	Product Information. Netspot (dotatate). Advanced Accelerator Applications, New York, NY.
50	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
51	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
52	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
53	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
54	Product Information. Octreoscan (indium pentetreotide In-111). Mallinckrodt Medical Inc, St. Louis, MO.
55	Cerner Multum, Inc. "Australian Product Information.".
56	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
57	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
58	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
59	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
60	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
61	Product Information. Lutathera (lutetium Lu 177 dotatate). Advanced Accelerator Applications, New York, NY.
62	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
63	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
64	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
65	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
66	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
67	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
68	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
69	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
70	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
71	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
72	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
73	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.

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