Drug General Information (ID: DDI21KORZM)
Drug Name			Digoxin		Drug Info		Moricizine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Antiarrhythmic Agents
Structure

Mechanism of Digoxin-Moricizine Interaction (Severity Level: Moderate)
Increased risk of atrioventricular block Click to Show/Hide Mechanism Graph
Drug Name		Digoxin				Moricizine
Mechanism		Delay atrioventricular conduction				Delay atrioventricular conduction
Key Mechanism Factor 1
		Factor Name		Atrioventricular block
		Factor Description		Atrioventricular block is a type of cardiac conduction block that occurs when the electrical signal from the atria to the ventricles is impaired. In an Atrioventricular block, this electrical signal is either delayed or completely blocked. When the signal is completely blocked, the ventricles produce their own electrical signal to control the heart rate. The heart rate produced by the ventricles is much slower than that produced by the sinus node.
Mechanism Description		Increased risk of atrioventricular block by the combination of Digoxin and Moricizine

Recommended Action
Management		The electrocardiogram should be closely monitored during coadministration.

References
1	Clyne CA, Estes NA, Wang PJ "Moricizine." N Engl J Med 327 (1992): 255-60. [PMID: 1614466]
2	MacFarland RT, Moeller VR, Pieniaszek HJ, Jr Whitney CC, Jr Marcus FI "Assessment of the potential pharmacokinetic interaction between digoxin and ethmozine." J Clin Pharmacol 25 (1985): 138-43
3	Kennedy HL, Sprague MK, Redd RM, Wiens RD, Blum RI, Buckingham TA "Serum digoxin concentrations during ethmozine antiarrhythmic therapy." Am Heart J 111 (1986): 667-72