Details of Drug

Details of Drug

 Drug General Information (ID: D1088)
  Drug Name
Moricizine
  Drug Type Small molecule
  Drug Synonymous
Moracizin; Moracizina; Moracizine; Moracizinum; Moricizine [USAN]; G 214; EN-313; Moracizina [INN-Spanish]; Moracizine (INN); Moracizinum [INN-Latin]; Moricizine (USAN); Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate; Ethyl 10-(beta-N-morpholinylpropionyl)phenothiazine-2-carbamate; Ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate; Phenothiazine-2-carbamic acid, 10-(3-morpholinopropionyl)-, ethyl ester; Ethyl [10-(3-morpholin-4-ylpropanoyl)-10H-phenothiazin-2-yl]carbamate; Ethyl {10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}carbamate; Ethyl N-{10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}carbamate; Ethyl (10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)carbamate; Carbamic acid, (10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)-, ethyl ester
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  Disease Class BC9Z: Cardiac arrhythmia; BC65: Genetic cardiac arrhythmia
  Therapeutic Class Antiarrhythmic Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C22H25N3O4S
  InChI 1S/C22H25N3O4S/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24/h3-8,15H,2,9-14H2,1H3,(H,23,27)
  InChIKey FUBVWMNBEHXPSU-UHFFFAOYSA-N
  Canonical SMILES CCOC(=O)NC1=CC2=C(C=C1)SC3=CC=CC=C3N2C(=O)CCN4CCOCC4
  External Link
Pubchem ID 34633
CAS Number 31883-05-3
CHEBI ID 6997
TTD ID D04VPA

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
BM017  CYP450 enzyme inhibition
BM049  Increased risk of atrioventricular block
BM051  Increased risk of bradycardia
BM076  Increased risk of prolong QT interval
BM078  Increased risk of rapid heart rate
  Relation Graph
 Full list of drugs interacting with Moricizine
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0337
 
Cimetidine
 
C10H16N6S
 
2756 
Moderate    Inter Info   
[16]
      Pharmacodynamic additive effects
   Increased risk of atrioventricular block Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0116
 
Atazanavir
 
C38H52N6O7
 
148192 
Major    Inter Info   
[6], [7]
D0514
 
Dolasetron
 
C19H20N2O3
 
3033818 
Major    Inter Info   
[11]
D0491
 
Digoxin
 
C41H64O14
 
2724385 
Moderate    Inter Info   
[16], [17], [18]
D0885
 
Lacosamide
 
C13H18N2O3
 
219078 
Moderate    Inter Info   
[29]
D1522
 
Sunitinib
 
C22H27FN4O2
 
5329102 
Moderate    Inter Info   
[37], [26]
   Increased risk of bradycardia Drug Num:  17
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Major    Inter Info   
[8], [9], [10]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Major    Inter Info   
[12], [13], [14]
D1474
 
Siponimod
 
C29H35F3N2O3
 
44599207 
Major    Inter Info   
[8], [15]
D0707
 
Galantamine
 
C17H21NO3
 
9651 
Moderate    Inter Info   
[19], [20], [21]
D0031
 
Alectinib
 
C30H34N4O2
 
49806720 
Moderate    Inter Info   
[22], [23]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[24]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Moderate    Inter Info   
[9], [25], [26]
D0516
 
Donepezil
 
C24H29NO3
 
3152 
Moderate    Inter Info   
[19], [20], [21]
D0661
 
Fingolimod
 
C19H33NO2
 
107970 
Moderate    Inter Info   
[27], [28]
D0891
 
Lanreotide
 
C54H69N11O10S2
 
71349 
Moderate    Inter Info   
[30], [31]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Moderate    Inter Info   
[32]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Moderate    Inter Info   
[33]
D1230
 
Pasireotide
 
C58H66N10O9
 
9941444 
Moderate    Inter Info   
[34], [8], [9], [35], [36]
D1418
 
Rivastigmine
 
C14H22N2O2
 
77991 
Moderate    Inter Info   
[19], [20], [21]
D1600
 
Tofacitinib
 
C16H20N6O
 
9926791 
Moderate    Inter Info   
[8], [26]
D1163
 
Octreotide
 
C49H66N10O10S2
 
448601 
Moderate    Inter Info   
[30], [31]
D1525
 
Tacrine
 
C13H14N2
 
1935 
Moderate    Inter Info   
[19], [20], [21]
   Increased risk of prolong QT interval Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0513
 
Dofetilide
 
C19H27N3O5S2
 
71329 
Major    Inter Info   
[1]
D0787
 
Ibutilide
 
C20H36N2O3S
 
60753 
Major    Inter Info   
[2], [3], [4]
   Increased risk of rapid heart rate Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0101
 
Arbutamine
 
C18H23NO4
 
60789 
Major    Inter Info   
[2], [3], [5]
References
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4 Product Information. Corvert (ibutilide). Pharmacia and Upjohn, Kalamazoo, MI.
5 Product Information. GenESA (arbutamine). Gensia Inc, San Diego, CA.
6 Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
7 Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
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9 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
10 Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
11 Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
12 Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
13 Product Information. Invirase (saquinavir mesylate). Astra USA, BAYER HLTHCARE, MA.
14 FDA. U.S. Food and Drug Administration "FDA drug safety communication: Ongoing safety review of Invirase (saquinavir) and possible association with abnormal heart rhythms."
15 Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
16 Clyne CA, Estes NA, Wang PJ "Moricizine." N Engl J Med 327 (1992): 255-60. [PMID: 1614466]
17 MacFarland RT, Moeller VR, Pieniaszek HJ, Jr Whitney CC, Jr Marcus FI "Assessment of the potential pharmacokinetic interaction between digoxin and ethmozine." J Clin Pharmacol 25 (1985): 138-43
18 Kennedy HL, Sprague MK, Redd RM, Wiens RD, Blum RI, Buckingham TA "Serum digoxin concentrations during ethmozine antiarrhythmic therapy." Am Heart J 111 (1986): 667-72
19 Product Information. Cognex (tacrine). Parke-Davis, Morris Plains, NJ.
20 Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
21 Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCI and digoxin: assessment of pharmacokinetic changes." Br J Clin Pharmacol 46(Suppl 1) (1998): 40-4
22 Product Information. Kaletra (lopinavir-ritonavir) Abbott Pharmaceutical, Abbott Park, IL.
23 Product Information. Alecensa (alectinib). Genentech, South San Francisco, CA.
24 Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
25 Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
26 Canadian Pharmacists Association "e-CPS."
27 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
28 FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
29 Product Information. Vimpat (lacosamide). UCB Pharma Inc, Smyrna, GA.
30 Product Information. Sandostatin (octreotide). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
31 Product Information. Somatuline Depot (lanreotide). Ipsen Inc, Milford, MA.
32 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
33 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
34 Canadian Pharmacists Association.
35 Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
36 Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
37 Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.