Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDI1PKR5A8)
  Drug Name Cisatracurium Drug Info Ranitidine (bismuth citrate) Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Neuromuscular Blocking Agents Antiulcer Agents
  Structure

 Mechanism of Cisatracurium-Ranitidine (bismuth citrate) Interaction (Severity Level: Minor)
     Antagonize the effect of neuromuscular blocking agents Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Cisatracurium Ranitidine (bismuth citrate)
      Mechanism Neuromuscular blocking agent
Neuronal acetylcholine receptor  Antagonist 		Attenuates neuromuscular blockade
      Key Mechanism Factor 1
Factor Name Neuronal acetylcholine receptor Structure Sequence
Protein Family Ligand-gated ion channel (TC 1.A.9) family
Protein Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    Click to Show/Hide
      Mechanism Description
  • Antagonize the effect of Cisatracurium when combined with Ranitidine (bismuth citrate) 

References
1 Katende RS, Dimich I "Resistance to nondepolarizing muscle relaxants in a patient treated with ranitidine." Mt Sinai J Med 54 (1987): 330-1. [PMID: 2955219]
2 McCarthy G, Mirakhur RK, Elliott P, Wright J "Effect of H2-receptor antagonist pretreatment on vecuronium- and atracurium-induced neuromuscular block." Br J Anaesth 66 (1991): 713-5. [PMID: 1676594]
3 Woodworth GE, Sears DH, Grove TM, et al "The effect of cimetidine and ranitidine on the duration of action of succinylcholine." Anesth Analg 68 (1989): 295-7. [PMID: 2919769]