Details of Drug-Drug Interaction
| Drug General Information (ID: DDI1LVEKQ7) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Amphotericin B (liposomal) | Drug Info | Licorice | Drug Info | |||||
| Drug Type | Small molecule | Natural product | |||||||
| Therapeutic Class | Antifungal Agents | Herbal Products | |||||||
| Structure | |||||||||
| Mechanism of Amphotericin B (liposomal)-Licorice Interaction (Severity Level: Moderate) | |||||||||
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| Increased risk of hypokalemia Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Amphotericin B (liposomal) | Licorice | |||||||
| Mechanism | Hypokalemia | Hypokalemia | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Hypokalemia | ||||||||
| Factor Description | Hypokalemia is a condition in which the amount of potassium in your blood is lower than normal. If you are mildly hypokalemic, you may not have any signs or symptoms, but severe hypokalemia may have the following symptoms: fatigue, constipation, frequent or heavy urination, muscle cramps or skin tingling, muscle weakness, and a fast or irregular heartbeat. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Patients should consult a healthcare provider before taking any herbal or alternative medicine. In general, chronic use of licorice and licorice-containing products should be avoided in patients treated with potassium-depleting drugs. During concomitant use, patients should be advised to contact their physician if they experience signs and symptoms of hypokalemia such as fatigue, myalgia, muscle weakness, abdominal pain, hypoventilation, and irregular heartbeat. | ||||||||