Drug General Information (ID: DDI14S7GHP)
Drug Name			Sucralfate		Drug Info		Cholic Acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gi Agents				Digestive Enzymes
Structure

Mechanism of Sucralfate-Cholic Acid Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Sucralfate				Cholic Acid
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Sucralfate due to formation of complexes caused by Cholic Acid

Recommended Action
Management		Cholic acid should be taken at least 1 hour before or 4 to 6 hours (or at as great an interval as possible) after a bile acid binding resin or aluminum-based antacid.

References
1	Product Information. Cholbam (cholic acid). Manchester Pharmaceutical, Fort Collins, CO.