Drug General Information (ID: DDI0VJ7QC6)
Drug Name			Norfloxacin		Drug Info		Magnesium hydroxide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antacids/Laxatives
Structure

Mechanism of Norfloxacin-Magnesium hydroxide Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Norfloxacin				Magnesium hydroxide
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Magnesium hydroxide due to formation of complexes caused by Norfloxacin

Recommended Action
Management		When coadministration cannot be avoided, quinolone antibiotics should be dosed either 2 to 4 hours before or 4 to 6 hours after polyvalent cation-containing products to minimize the potential for interaction.

References
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18	Product Information. Baxdela (delafloxacin). Melinta Therapeutics, Lincolnshire, IL.
19	Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.
20	Product Information. Levaquin (levofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
21	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
22	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
23	Product Information. Trovan (trovafloxacin). Pfizer US Pharmaceuticals, New York, NY.
24	Product Information. Zagam (sparfloxacin). Rhone-Poulenc Rorer, Collegeville, PA.
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