Drug General Information (ID: DDI0SW9AGQ)
Drug Name			Sucralfate		Drug Info		Deferasirox		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gi Agents				Chelating Agents
Structure

Mechanism of Sucralfate-Deferasirox Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Sucralfate				Deferasirox
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Sucralfate due to formation of complexes caused by Deferasirox

Recommended Action
Management		Deferasirox should not be taken with aluminum-containing preparations.

References
1	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.