Drug General Information (ID: DDI05HJIN1)
Drug Name			Methoxsalen		Drug Info		Alimemazine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antihistamines
Structure

Mechanism of Methoxsalen-Alimemazine Interaction (Severity Level: Moderate)
Increased risk of photosensitivity reactions Click to Show/Hide Mechanism Graph
Drug Name		Methoxsalen				Alimemazine
Mechanism		Photosensitivity reactions				Photosensitivity reactions
Key Mechanism Factor 1
		Factor Name		Photosensitivity reactions
		Factor Description		Drug-induced photosensitivity reactions occur when certain photosensitizing drugs cause unexpected sunburn or dermatitis (dry, bumpy or blistering rash) on sun-exposed skin (face, neck, arms, backs of hands, and often lower legs and feet). The rash may or may not be itchy.
Mechanism Description		Increased risk of photosensitivity reactions by the combination of Methoxsalen and Alimemazine

Recommended Action
Management		Caution is advised and pharmacologic response to methoxsalen therapy should be carefully monitored if concomitant use of other photosensitizing agents cannot be avoided. Patients should be advised to avoid sun exposure, even through window glass or cloud cover, for at least 8 hours after methoxsalen ingestion and during the 24 hours following photochemotherapy or photopheresis treatment.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Multum Information Services, Inc. Expert Review Panel.
3	Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.