Details of Drug

Drug General Information (ID: D1028)
Drug Name	Methoxsalen
Drug Type	Small molecule
Drug Synonymous	Ammodin; Ammoidin; Deltasoralen; Dermox; Geroxalen; Meladinin; Meladinina; Meladinine; Meladoxen; Meloxine; Methoxalen; Methoxaten; Oxoralen; Oxsoralen; Oxypsoralen; Puvalen; Puvamet; Ultramop; Uvadex; XANTHOTOXIN; Xanthotoxine; Zanthotoxin; Boehringer Ingelheim Brand of Methoxsalen; Canderm Brand of Methoxsalen; Chinoin Brand of Methoxsalen; DB Brand of Methoxsalen; Delta Brand of Methoxsalen; Dermatech Brand of Methoxsalen; Galderma Brand of Methoxsalen; Methoxa Dome; Methoxsalen Canderm Brand; Methoxsalen Chinoin Brand; Methoxsalen Delta Brand; Methoxsalen Dermatech Brand; Methoxsalen plus ultraviolet radiation; Mex America Brand of Methoxsalen; Oxsoralen Ul tra; Oxsoralen Ultra; Oxsoralen lotion; Sanofi Synthelabo Brand of Methoxsalen; Ultra Mop; Ultramop Lotion; ICN Brand 1 of Methoxsalen; ICN Brand 2 of Methoxsalen; ICN Brand 3 of Methoxsalen; X0009; An 8-methoxyfurocoumarin; Meladinin (VAN); Methoxa-Dome; Methoxsalen Mex-America Brand; Methoxsalen Sanofi-Synthelabo Brand; Methoxsalen [BAN:JAN]; Methoxsalen with ultra-violet A theraphy; Mex-America Brand of Methoxsalen; New-Meladinin; O-methylxanthotoxol; OXSORALEN (TN); Oxsoralen (TN); Oxsoralen-ultra; Proralone-mop; Psoralen-mop; Psoralon-MOP; Sanofi-Synthelabo Brand of Methoxsalen; Methoxsalen (JP15/USP); Methoxy-8-psoralen; 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, .delta.-lactone; 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone; 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactone; 7-Furocoumarin; 8 Methoxypsoralen; 8-METHOXYPSORALEN + UVA (SEE ALSO C55903); 8-MOP; 8-Methoxy; 8-Methoxy(furano-3'.2':6.7-coumarin); 8-Methoxy-(furano-3'.2':6.7-coumarin); 8-Methoxy-2',3',6,7-furocoumarin; 8-Methoxy-4',5',6,7-furocoumarin; 8-Methoxy-4',5':6,7-furocoumarin; 8-Methoxy-[furano-3'.2':6.7-coumarin]; 8-Methoxyfuranocoumarin; 8-Methoxypsoralen; 8-Methoxypsoralen with ultraviolet A therapy; 8-Methoxypsoralene; 8-methoxyfuranocoumarins; 8-methoxyfurocoumarins; 8MO; 8MOP; 9-(methyloxy)-7H-furo[3,2-g]chromen-7-one; 9-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one; 9-Methoxy-7H-furo(3,2-g)benzopyran-7-one; 9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one; 9-Methoxy-7H-furo[3,2-g]chromen-7-one; 9-Methoxyfuro(3,2-g)chromen-7-one; 9-Methoxyfuro[3,2-g][1]benzopyran-7-one; 9-Methoxypsoralen; 9-metho xy-7H-furo(3,2-g)benzopyran-7-one; 9-methoxyfuro[3,2-g]chromen-7-one Click to Show/Hide
Disease Class	2B01: Mycosis fungoides; EA90: Psoriasis
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C12H8O4
InChI	1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3
InChIKey	QXKHYNVANLEOEG-UHFFFAOYSA-N
Canonical SMILES	COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2
External Link
	Pubchem ID	4114
	CAS Number	298-81-7
	CHEBI ID	18358
	TTD ID	D08SKH
	INTEDE ID	DR1047
	VARIDT ID	DR00920

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM075 Increased risk of photosensitivity reactions
Relation Graph

Full list of drugs interacting with Methoxsalen
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1385		Rasagiline	C12H13N	3052776	Major		Inter Info	[3], [4], [5]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[17]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[18], [19]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[4], [20]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[23]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[24], [25], [26], [27], [28]
Pharmacodynamic additive effects
	Increased risk of photosensitivity reactions					Drug Num: 114
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[1], [2]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0018		Acitretin	C21H26O3	5284513	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0024		Adapalene (topical)	C28H28O3	60164	Moderate		Inter Info	[3], [14], [16]
D0039		Alitretinoin (topical)	C20H28O2	449171	Moderate		Inter Info	[3], [14], [16]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0179		Bexarotene (topical)	C24H28O2	82146	Moderate		Inter Info	[3], [14], [16]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0306		Cetuximab	NA	NA	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0531		Doxycycline (topical)	C22H24N2O8	54671203	Moderate		Inter Info	[3], [14], [16]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0031		Alectinib	C30H34N4O2	49806720	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[3], [14], [16]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[3], [14], [16]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0340		Cinoxacin	C12H10N2O5	2762	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0374		Coal tar (topical)	NA	NA	Moderate		Inter Info	[3], [14], [16]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0589		Eravacycline	C27H31FN4O8	54726192	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[3], [14], [16]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0757		Hexachlorophene (topical)	C13H6Cl6O2	3598	Moderate		Inter Info	[3], [14], [16]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0796		Imiquimod (topical)	C14H16N4	57469	Moderate		Inter Info	[3], [14], [16]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[3], [14], [1], [15], [16]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[3], [14], [16]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1071		Minocycline (topical)	C23H27N3O7	54675783	Moderate		Inter Info	[3], [14], [16]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1175		Omadacycline	C29H40N4O7	54697325	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1209		Oxytetracycline	C22H24N2O9	54675779	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1220		Panitumumab	NA	NA	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[21], [4], [22]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1514		Sulfadoxine	C12H14N4O4S	17134	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1515		Sulfamethizole	C9H10N4O2S2	5328	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1537		Tazarotene (topical)	C21H21NO2S	5381	Moderate		Inter Info	[3], [14], [16]
D1564		Tetracycline	C22H24N2O8	54675776	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1565		Tetracycline (topical)	C22H24N2O8	54675776	Moderate		Inter Info	[3], [14], [16]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1582		Tigecycline	C29H39N5O8	54686904	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1627		Tretinoin (topical)	C20H28O2	444795	Moderate		Inter Info	[3], [14], [16]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1636		Trifarotene (topical)	C29H33NO4	11518241	Moderate		Inter Info	[3], [14], [16]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1648		Trioxsalen	C14H12O3	5585	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1513		Sulfadiazine	C10H10N4O2S	5215	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1519		Sulfisoxazole	C11H13N3O3S	5344	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[3], [14], [16]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[3], [14], [1], [15], [16]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[3], [14], [1], [15], [16]

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