Details of Drug | MecDDI

Drug General Information (ID: D1886)
Drug Name		Secretin human
Drug Type		Hormones
Drug Synonymous		Secretin human\|Secretin, unspecified\|Secretin human [INN]\|CHEMBL3039582\|Secretin (human, porcine, etc.)\|NCGC00167148-01\|Secretin (pig), 15-L-glutamic acid-16-glycine-\|L-Histidyl-L-seryl-L-a-aspartylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-a-glutamyl-L-leucyl-L-seryl-L-arginyl-L-leucyl-L-arginyl-L-a-glutamylglycyl -L-alanyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminylglycyl-L-leucyl-L-valinamide\|L-Valinamide, L-histidyl-L-seryl-L-.alpha.-aspartylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-.alpha.-glutamyl-L-leucyl-L-seryl-L-arginyl-L-leucyl-L-arginyl-L-.alpha.-glutamylglycyl-L-alanyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminylglycyl-L-leucyl- Click to Show/Hide
Therapeutic Class		Hormone Modulators
Structure
Structure		3D Structure				2D Structure
Formula		C130H220N44O40
InChI		InChI=1S/C130H220N44O40/c1-60(2)43-81(120(208)173-100(66(13)14)103(134)191)153-95(183)54-149-106(194)77(31-35-92(132)180)159-116(204)84(46-63(7)8)166-118(206)85(47-64(9)10)164-111(199)75(29-23-41-146-129(139)140)155-113(201)79(32-36-93(133)181)160-117(205)83(45-62(5)6)162-110(198)73(27-21-39-144-127(135)136)154-104(192)67(15)152-94(182)53-148-107(195)78(33-37-97(185)186)158-109(197)74(28-22-40-145-128(137)138)156-115(203)82(44-61(3)4)163-112(200)76(30-24-42-147-130(141)142)157-122(210)90(57-176)170-119(207)86(48-65(11)12)165-114(202)80(34-38-98(187)188)161-123(211)91(58-177)171-126(214)102(69(17)179)174-121(209)87(49-70-25-19-18-20-26-70)168-125(213)101(68(16)178)172-96(184)55-150-108(196)88(51-99(189)190)167-124(212)89(56-175)169-105(193)72(131)50-71-52-143-59-151-71/h18-20,25-26,52,59-69,72-91,100-102,175-179H,21-24,27-51,53-58,131H2,1-17H3,(H2,132,180)(H2,133,181)(H2,134,191)(H,143,151)(H,148,195)(H,149,194)(H,150,196)(H,152,182)(H,153,183)(H,154,192)(H,155,201)(H,156,203)(H,157,210)(H,158,197)(H,159,204)(H,160,205)(H,161,211)(H,162,198)(H,163,200)(H,164,199)(H,165,202)(H,166,206)(H,167,212)(H,168,213)(H,169,193)(H,170,207)(H,171,214)(H,172,184)(H,173,208)(H,174,209)(H,185,186)(H,187,188)(H,189,190)(H4,135,136,144)(H4,137,138,145)(H4,139,140,146)(H4,141,142,147)/t67-,68+,69+,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,100-,101-,102-/m0/s1
InChIKey		OWMZNFCDEHGFEP-NFBCVYDUSA-N
Canonical SMILES		C[C@H]([C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CN=CN2)N)O
External Link
External Link		Pubchem ID		16158474

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM007 Pharmacodynamic antagonistic effects BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Secretin human
Pharmacodynamic antagonistic effects
					Attenuated pharmacological effects (Unspecific)																																																																Drug Num: 10
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D0123															Atropine															C17H23NO3															174174															Minor															Inter Info													[1], [2]
D0353															Clidinium															C22H26NO3+															2784															Minor															Inter Info													[1], [2]
D0482															Dicyclomine															C19H35NO2															3042															Minor															Inter Info													[1], [2]
D0733															Glycopyrronium															C19H28NO3+															3494															Minor															Inter Info													[1], [2]
D0782															Hyoscyamine															C17H23NO3															154417															Minor															Inter Info													[1], [2]
D1000															Mepenzolate															C21H26NO3+															4057															Minor															Inter Info													[1], [2]
D1354															Propantheline															C23H30NO3+															4934															Minor															Inter Info													[1], [2]
D1450															Scopolamine															C17H21NO4															3000322															Minor															Inter Info													[1], [2]
D0154															Belladonna															C34H42N2O4															265028															Minor															Inter Info													[1], [2]
D1031															Methscopolamine															C18H24NO4+															71183															Minor															Inter Info													[1], [2]

References
1	Ebert U, Oertel R, Kirch W "Influence of grapefruit juice on scopolamine pharmacokinetics and pharmacodynamics in healthy male and female subjects." Int J Clin Pharm Therapeutics 38 (2000): 523-31. [PMID: 11097144]
2	Pearson RM, Breckenridge AM "Renal function, protein binding and pharmacological response to diazoxide." Br J Clin Pharmacol 3 (1976): 169-75. [PMID: 973937]