Details of Drug

Drug General Information (ID: D1714)
Drug Name	Zafirlukast
Drug Type	Small molecule
Drug Synonymous	Accolate; Accoleit; Aeronix; Olmoran; Respix; Zafirst; AstraZeneca brand of zafirlukast; Menarini brand of zafirlukast; Novartis brand of zafirlukast; Zeneca brand of zafirkulast; Accolate (TN); Accoleit (TN); Vanticon (TN); Zafirlukast [USAN:BAN:INN]; Accolate, Accoleit, Vanticon, Zafirlukast; Zafirlukast (JAN/USAN/INN); Cyclopentyl N-[3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methylindol-5-yl]carbamate; Cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate; Cyclopentyl 3-[2-methoxy-4-(2-methylphenylsulfonylcarbamoyl)benzyl]-1-methyl-1H-indol-5-ylcarbamate; Cyclopentyl [3-(2-methoxy-4-{[(2-methylphenyl)sulfonyl]carbamoyl}benzyl)-1-methyl-1H-indol-5-yl]carbamate; Cyclopentyl (1-methyl-3-{[2-(methyloxy)-4-({[(2-methylphenyl)sulfonyl]amino}carbonyl)phenyl]methyl}-1H-indol-5-yl)carbamate; Carbamic acid, (3-((2-methoxy-4-((((2-methylphenyl)sulfonyl)amino)carbonyl)phenyl)methyl)-1-methyl-1H-indol-5-yl)-, cyclopentyl ester; 4-(5-cyclopentyloxy-carbonylamino-1-methyl-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide; 4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide; 4-(5-cyclopentyloxycarbonylamino-2-methylindol-3-yl-methyl)-3-methoxy-N-O-tolylsulfonylbenzamide Click to Show/Hide
Disease Class	CA23: Asthma
Therapeutic Class	Antiasthmatic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C31H33N3O6S
InChI	1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35)
InChIKey	YEEZWCHGZNKEEK-UHFFFAOYSA-N
Canonical SMILES	CC1=CC=CC=C1S(=O)(=O)NC(=O)C2=CC(=C(C=C2)CC3=CN(C4=C3C=C(C=C4)NC(=O)OC5CCCC5)C)OC
External Link
	Pubchem ID	5717
	CAS Number	107753-78-6
	CHEBI ID	10100
	TTD ID	D05DVP
	INTEDE ID	DR1723
	VARIDT ID	DR00872

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM031 Increased renal excretion (Unspecific) BM055 Increased risk of hepatotoxicity BM074 Increased risk of peripheral neuropathy
Relation Graph

Full list of drugs interacting with Zafirlukast
Affected cellular transport
	Transporter inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[159], [14], [35], [160], [161], [162], [163], [164], [165]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[14], [35], [190]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 119
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1], [2], [3], [4], [5]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[6], [7], [8], [9], [10]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[14], [15]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[16], [17]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[18]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[17]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[14], [21], [22], [23], [24], [25], [26], [27], [28]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[47]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[48]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[49], [50]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[51], [52], [53]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[54], [55], [56], [57], [58], [22], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[78]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[79]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[83], [84]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[60], [62], [73]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[60], [62], [73]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[89], [90]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[11], [14], [91]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[14], [35], [92]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[93], [94], [95], [96]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[99], [100], [101]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[102]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[103], [50]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[104], [105], [35], [106], [107], [108], [109], [110], [111], [112], [113], [114], [50], [115], [116], [5], [117]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[51], [52], [53]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[120]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[121]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[35], [122]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[35], [123]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[35], [126]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[14], [35], [128]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[129], [14], [35], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[129], [14], [35]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[143]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[35], [145]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[146]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[147], [148], [149], [150], [151], [152], [153], [154], [155]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[157]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[166]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[167]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[170]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[171]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[172]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[60], [62], [73]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[54], [55], [56], [57], [58], [22], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[173], [50]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[14], [35], [174]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[175]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[176]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[177]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[35], [178]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[52], [179]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[35], [180]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[182]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[11], [14], [35], [183], [184], [185], [186]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[14], [35], [183]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[187], [188]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[189]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[191]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[192]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[193]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[194]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[14], [35], [195], [50]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[196]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[197]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[199], [200]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[201], [202]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[204], [205]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[206]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[207]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[35], [208]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[209]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[210]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[211], [212]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[35], [213]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[214]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[215]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[216], [217], [218], [219], [220], [221], [222]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[14], [35], [223]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[14], [225], [35], [226]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[14], [227]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[228]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[35], [229]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[35], [230]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[231]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[232]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[233]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[234]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[235]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[236]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[237]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[239], [240]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[35], [241], [242]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[243]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[244]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[245]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[246], [50]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[14], [35], [247]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[14], [35], [248]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[51], [52], [53]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[250], [251]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[252], [253], [254], [255], [256], [257], [258]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[259], [260]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[261]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[262], [263], [264], [265], [266], [267], [268]
D0080		Amprenavir	C25H35N3O6S	65016	Minor		Inter Info	[269]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[14], [270], [271]
D0364		Clopidogrel	C16H16ClNO2S	60606	Minor		Inter Info	[272]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[273], [274], [275], [276]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[277]
D0599		Escitalopram	C20H21FN2O	146570	Minor		Inter Info	[259], [260]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[278]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[14], [270], [271]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[279]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[35], [280]
D1464		Sibutramine	C17H26ClN	5210	Minor		Inter Info	[281]
D1664		Ulipristal	C28H35NO3	13559281	Minor		Inter Info	[35], [282]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[283], [284], [285], [286]
	CYP450 enzyme induction					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[118]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[119]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[125]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[35], [158]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[119]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[224], [53]
D1415		Ritonavir	C37H48N6O5S2	392622	Minor		Inter Info	[257]
Affected excretion pathways
	Increased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[52], [81], [82]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[11], [12], [13]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[19]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[20]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[11], [12], [13]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[32], [33], [34], [14], [35], [36], [37], [38], [39], [40], [41], [42], [43]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[14], [35], [80]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[85], [86], [87], [88]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[85], [86], [87], [88]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[32], [33], [34], [14], [35], [36], [37], [38], [39], [40], [41], [42], [43]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[97], [98]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[32], [33], [34], [14], [35], [36], [37], [38], [39], [40], [41], [42], [43]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[124]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[52], [127]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[32], [33], [34], [14], [35], [36], [37], [38], [39], [40], [41], [42], [43]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[35], [144]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[156]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[168], [169]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[181]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[35], [198]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[203]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[85], [86], [87], [88]
	Increased risk of peripheral neuropathy					Drug Num: 72
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[44], [45], [46]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[29], [30], [31]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[29], [30], [31]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[29], [30], [31]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[29], [30], [31]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[29], [30], [31]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[29], [30], [31]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[29], [30], [31]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[29], [30], [31]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[29], [30], [31]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[29], [30], [31]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[29], [30], [31]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[29], [30], [31]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[29], [30], [31]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[29], [30], [31]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[29], [30], [31]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[29], [30], [31]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[29], [30], [31]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[29], [30], [31]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[29], [30], [31]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[29], [30], [31]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[29], [30], [31]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[29], [30], [31]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[29], [30], [31]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[29], [30], [31]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[29], [30], [31]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[29], [30], [31]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[29], [30], [31]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[29], [30], [31]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[29], [30], [31]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[29], [30], [31]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[29], [30], [31]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[29], [30], [31]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[29], [30], [31]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[29], [30], [31]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[29], [30], [31]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[29], [30], [31]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[29], [30], [31]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[29], [30], [31]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[29], [30], [31]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[29], [30], [31]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[29], [30], [31]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[29], [30], [31]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[29], [30], [31]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[29], [30], [31]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[29], [30], [31]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[29], [30], [31]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[29], [30], [31]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[29], [30], [31]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[29], [30], [31]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[29], [30], [31]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[29], [30], [31]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[44], [14], [35], [238]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[29], [30], [31]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[44], [249]

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170	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
171	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
172	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
173	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
174	Product Information. Antara (fenofibrate). Lupin Pharmaceuticals Inc, Baltimore, MD.
175	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
176	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
177	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
178	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
179	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
180	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
181	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
182	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
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186	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
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188	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
189	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
190	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
191	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
192	Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
193	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
194	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
195	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
196	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
197	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
198	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
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201	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
202	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
203	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
204	Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
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207	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
208	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
209	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
210	Product Information. Osphena (ospemifene). Shionogi USA Inc, Florham Park, NJ.
211	Hamberg P, Woo MM, Chen LC, et al. "Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor." Cancer Chemother Pharmacol 68 (2011): 805-13. [PMID: 21706316]
212	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
213	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
214	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
215	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
216	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
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220	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
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224	Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
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227	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
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229	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
230	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
231	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
232	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
233	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
234	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
235	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
236	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
237	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
238	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
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243	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
244	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
245	Product Information. Bextra (valdecoxib). Pharmacia Corporation, Peapack, NJ.
246	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
247	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
248	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
249	Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.
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260	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
261	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.
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270	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
271	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
272	Product Information. Plavix (clopidogrel). Bristol-Myers Squibb, Princeton, NJ.
273	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
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277	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
278	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
279	Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
280	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
281	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
282	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
283	Miceli JJ, Smith M, Robarge L, Morse T, Laurent A "The effects of ketoconazole on ziprasidone pharmacokinetics--a placebo-controlled crossover study in healthy volunteers." Br J Clin Pharmacol 49(suppl 1) (2000): s71-6. [PMID: 10771458]
284	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
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